Paper ID: 2312.01152

Ultra-Resolution Cascaded Diffusion Model for Gigapixel Image Synthesis in Histopathology

Sarah Cechnicka, Hadrien Reynaud, James Ball, Naomi Simmonds, Catherine Horsfield, Andrew Smith, Candice Roufosse, Bernhard Kainz

Diagnoses from histopathology images rely on information from both high and low resolutions of Whole Slide Images. Ultra-Resolution Cascaded Diffusion Models (URCDMs) allow for the synthesis of high-resolution images that are realistic at all magnification levels, focusing not only on fidelity but also on long-distance spatial coherency. Our model beats existing methods, improving the pFID-50k [2] score by 110.63 to 39.52 pFID-50k. Additionally, a human expert evaluation study was performed, reaching a weighted Mean Absolute Error (MAE) of 0.11 for the Lower Resolution Diffusion Models and a weighted MAE of 0.22 for the URCDM.

Submitted: Dec 2, 2023