Paper ID: 2401.08712

Survival Analysis of Young Triple-Negative Breast Cancer Patients

M. Mehdi Owrang O, Fariba Jafari Horestani, Ginger Schwarz

Breast cancer prognosis is crucial for effective treatment, with the disease more common in women over 40 years old but rare under 40 years old, where less than 5 percent of cases occur in the U.S. Studies indicate a worse prognosis in younger women, which varies by ethnicity. Breast cancers are classified based on receptors like estrogen, progesterone, and HER2. Triple-negative breast cancer (TNBC), lacking these receptors, accounts for about 15 percent of cases and is more prevalent in younger patients, often resulting in poorer outcomes. Nevertheless, the impact of age on TNBC prognosis remains unclear. Factors like age, race, tumor grade, size, and lymph node status are studied for their role in TNBC's clinical outcomes, but current research is inconclusive about age-related differences. This study uses SEER data set to examine the influence of younger age on survivability in TNBC patients, aiming to determine if age is a significant prognostic factor. Our experimental results on SEER dataset confirm the existing research reports that TNBC patients have worse prognosis compared to non-TNBC based on age. Our main goal was to investigate whether younger age has any significance on the survivability of TNBC patients. Experimental results do not show that younger age has any significance on the prognosis and survival rate of the TNBC patients

Submitted: Jan 15, 2024