Paper ID: 2405.20614

EPIDetect: Video-based convulsive seizure detection in chronic epilepsy mouse model for anti-epilepsy drug screening

Junming Ren, Zhoujian Xiao, Yujia Zhang, Yujie Yang, Ling He, Ezra Yoon, Stephen Temitayo Bello, Xi Chen, Dapeng Wu, Micky Tortorella, Jufang He

In the preclinical translational studies, drug candidates with remarkable anti-epileptic efficacy demonstrate long-term suppression of spontaneous recurrent seizures (SRSs), particularly convulsive seizures (CSs), in mouse models of chronic epilepsy. However, the current methods for monitoring CSs have limitations in terms of invasiveness, specific laboratory settings, high cost, and complex operation, which hinder drug screening efforts. In this study, a camera-based system for automated detection of CSs in chronically epileptic mice is first established to screen potential anti-epilepsy drugs.

Submitted: May 31, 2024