Paper ID: 2501.02176

Molecule-dynamic-based Aging Clock and Aging Roadmap Forecast with Sundial

Wei Wu, Zizhen Deng, Chi Zhang, Can Liao, Jinzhuo Wang

Addressing the unavoidable bias inherent in supervised aging clocks, we introduce Sundial, a novel framework that models molecular dynamics through a diffusion field, capturing both the population-level aging process and the individual-level relative aging order. Sundial enables unbiasedestimation of biological age and the forecast of aging roadmap. Fasteraging individuals from Sundial exhibit a higher disease risk compared to those identified from supervised aging clocks. This framework opens new avenues for exploring key topics, including age- and sex-specific aging dynamics and faster yet healthy aging paths.

Submitted: Jan 4, 2025