Alzheimer'S Disease
Alzheimer's disease (AD) research focuses on improving early and accurate diagnosis to facilitate timely intervention. Current efforts utilize diverse data sources (MRI, EEG, speech, genetics) and advanced machine learning models, including convolutional neural networks (CNNs), transformers, and Bayesian networks, to identify disease biomarkers and predict progression. These advancements aim to enhance diagnostic accuracy, personalize treatment strategies, and ultimately improve patient outcomes, though challenges remain in data standardization, model interpretability, and generalizability across diverse populations. The integration of multimodal data and explainable AI techniques is a key trend to improve both predictive power and clinical utility.
Papers
Alzheimer's disease detection in PSG signals
Lorena Gallego-Viñarás, Juan Miguel Mira-Tomás, Anna Michela-Gaeta, Gerard Pinol-Ripoll, Ferrán Barbé, Pablo M. Olmos, Arrate Muñoz-Barrutia
Analyzing heterogeneity in Alzheimer Disease using multimodal normative modeling on imaging-based ATN biomarkers
Sayantan Kumar, Tom Earnest, Braden Yang, Deydeep Kothapalli, Andrew J. Aschenbrenner, Jason Hassenstab, Chengie Xiong, Beau Ances, John Morris, Tammie L. S. Benzinger, Brian A. Gordon, Philip Payne, Aristeidis Sotiras