Biomarker Prediction
Biomarker prediction aims to identify and quantify disease indicators directly from medical images, such as histopathology slides or MRI scans, using machine learning. Current research heavily utilizes deep learning models, including vision transformers and convolutional neural networks, often employing multi-task learning and self-supervised pre-training strategies to improve accuracy and generalizability across diverse cancer types and biomarkers. This field holds significant promise for accelerating diagnosis, personalizing treatment selection, and improving patient outcomes by providing a faster, cheaper, and potentially more comprehensive alternative to traditional molecular assays.
Papers
Joint multi-task learning improves weakly-supervised biomarker prediction in computational pathology
Omar S. M. El Nahhas, Georg Wölflein, Marta Ligero, Tim Lenz, Marko van Treeck, Firas Khader, Daniel Truhn, Jakob Nikolas Kather
Hitchhiker's guide to cancer-associated lymphoid aggregates in histology images: manual and deep learning-based quantification approaches
Karina Silina, Francesco Ciompi