Computational Pathology
Computational pathology applies computational methods, primarily deep learning, to analyze digitized histopathology slides, aiming to improve diagnostic accuracy, efficiency, and accessibility. Current research emphasizes developing robust and generalizable models, focusing on architectures like Vision Transformers, Multiple Instance Learning (MIL), and foundation models, often incorporating multimodal data (e.g., pathology reports, gene expression) and addressing challenges like domain generalization and efficient WSI representation. This field holds significant promise for improving cancer diagnosis and prognosis, accelerating research, and potentially reducing the workload on pathologists.
Papers
Benchmarking Embedding Aggregation Methods in Computational Pathology: A Clinical Data Perspective
Shengjia Chen, Gabriele Campanella, Abdulkadir Elmas, Aryeh Stock, Jennifer Zeng, Alexandros D. Polydorides, Adam J. Schoenfeld, Kuan-lin Huang, Jane Houldsworth, Chad Vanderbilt, Thomas J. Fuchs
Towards a text-based quantitative and explainable histopathology image analysis
Anh Tien Nguyen, Trinh Thi Le Vuong, Jin Tae Kwak
FALFormer: Feature-aware Landmarks self-attention for Whole-slide Image Classification
Doanh C. Bui, Trinh Thi Le Vuong, Jin Tae Kwak
Morphological Prototyping for Unsupervised Slide Representation Learning in Computational Pathology
Andrew H. Song, Richard J. Chen, Tong Ding, Drew F. K. Williamson, Guillaume Jaume, Faisal Mahmood
Transcriptomics-guided Slide Representation Learning in Computational Pathology
Guillaume Jaume, Lukas Oldenburg, Anurag Vaidya, Richard J. Chen, Drew F. K. Williamson, Thomas Peeters, Andrew H. Song, Faisal Mahmood
PRISM: A Multi-Modal Generative Foundation Model for Slide-Level Histopathology
George Shaikovski, Adam Casson, Kristen Severson, Eric Zimmermann, Yi Kan Wang, Jeremy D. Kunz, Juan A. Retamero, Gerard Oakley, David Klimstra, Christopher Kanan, Matthew Hanna, Michal Zelechowski, Julian Viret, Neil Tenenholtz, James Hall, Nicolo Fusi, Razik Yousfi, Peter Hamilton, William A. Moye, Eugene Vorontsov, Siqi Liu, Thomas J. Fuchs
Region of Interest Detection in Melanocytic Skin Tumor Whole Slide Images -- Nevus & Melanoma
Yi Cui, Yao Li, Jayson R. Miedema, Sharon N. Edmiston, Sherif Farag, J. S. Marron, Nancy E. Thomas