G Protein Coupled Receptor
G protein-coupled receptors (GPCRs) are a large family of cell surface receptors crucial for numerous biological processes, targeted by over one-third of FDA-approved drugs. Current research focuses on improving drug discovery and understanding GPCR function through machine learning techniques, including recurrent neural networks for de novo drug design, convolutional neural networks for analyzing imaging data (e.g., FTIR, MRI), and transformer-based models for interpreting protein sequences and predicting receptor dynamics. These advancements are significantly impacting drug development by accelerating the identification of novel ligands, predicting adverse effects, and enhancing our understanding of GPCR structure-function relationships, ultimately leading to safer and more effective therapies.