Single Cell
Single-cell analysis focuses on understanding the heterogeneity of individual cells within a population, aiming to decipher cellular functions and behaviors in health and disease. Current research heavily utilizes deep learning models, including variational autoencoders, transformers, and graph neural networks, to analyze high-dimensional single-cell data (e.g., RNA sequencing, imaging) and integrate information across multiple modalities. These advancements enable improved cell type identification, trajectory inference, and prediction of cellular responses to perturbations, with significant implications for disease diagnostics, drug discovery, and personalized medicine.
Papers
Uncertainty Quantification for Atlas-Level Cell Type Transfer
Jan Engelmann, Leon Hetzel, Giovanni Palla, Lisa Sikkema, Malte Luecken, Fabian Theis
Learning Causal Representations of Single Cells via Sparse Mechanism Shift Modeling
Romain Lopez, Nataša Tagasovska, Stephen Ra, Kyunghyn Cho, Jonathan K. Pritchard, Aviv Regev