Single Cell
Single-cell analysis focuses on understanding the heterogeneity of individual cells within a population, aiming to decipher cellular functions and behaviors in health and disease. Current research heavily utilizes deep learning models, including variational autoencoders, transformers, and graph neural networks, to analyze high-dimensional single-cell data (e.g., RNA sequencing, imaging) and integrate information across multiple modalities. These advancements enable improved cell type identification, trajectory inference, and prediction of cellular responses to perturbations, with significant implications for disease diagnostics, drug discovery, and personalized medicine.
Papers
Confident Clustering via PCA Compression Ratio and Its Application to Single-cell RNA-seq Analysis
Yingcong Li, Chandra Sekhar Mukherjee, Jiapeng Zhang
scICML: Information-theoretic Co-clustering-based Multi-view Learning for the Integrative Analysis of Single-cell Multi-omics data
Pengcheng Zeng, Zhixiang Lin