Structure Determination

Structure determination aims to elucidate the three-dimensional arrangement of atoms in molecules or objects, crucial for understanding their function and properties. Current research focuses on developing advanced computational methods, including generative diffusion models and neural radiance fields, to overcome limitations of traditional experimental techniques like X-ray crystallography and cryo-EM, particularly in handling noisy or incomplete data. These advancements are improving the accuracy and efficiency of structure determination across diverse applications, from protein structure prediction to robotic grasping and the analysis of complex molecules like RNA. The resulting improvements in structural resolution have significant implications for various fields, including drug discovery, materials science, and fundamental biological research.