Post-training quantization (PTQ) methods for large language models compress pretrained weights to low bit-widths without retraining by optimizing layer-local proxy objectives. Activation-aware scaling methods such as AWQ protect input channels with large activation norms, whereas second-order error-compensation methods such as GPTQ redistribute rounding error using the inverse of the unweighted input covariance matrix. We show that both paradigms -- along with diagonal Fisher quantization, block reconstruction, and Hadamard rotation methods -- are special cases of minimizing a single loss-derived quadratic form governed by gradient-weighted activation sensitivity. From a Gauss-Newton expansion of the task loss at a linear layer
Y=XW⊤, we prove that under isotropic output curvature the expected excess loss from weight perturbation
ΔW reduces to
2dout1Tr(ΔWHDΔW⊤), where
HD=n1X⊤DX weights each calibration token's outer product by its squared output-gradient norm
Dtt=∥∇ytL∥22. Within this framework, AWQ corresponds to a diagonal approximation of
HD with uniform token weights (
D=In) optimized via channel scaling, while GPTQ corresponds to Cholesky error compensation on
HD under
D=In. We derive closed-form optimal scaling exponents for diagonal sensitivity protection, formulate sensitivity-weighted Cholesky quantization (SAQ-GPTQ) on
HD, and prove bounds on token-gradient heterogeneity bias, cross-layer error amplification across residual blocks, and finite-sample calibration concentration. Controlled numerical simulations confirm that under token-gradient heterogeneity, replacing
X⊤X with
X⊤DX preserves
>99% top-channel saliency recall and reduces INT3/INT4 excess loss by roughly
3× over unweighted GPTQ.