Hypothesis-Conditioned Query Rewriting for Decision-Useful Retrieval

Retrieval-augmented generation (RAG) grounds large language models in external medical knowledge, yet standard retrievers frequently surface hard negatives that are semantically close to the query but describe clinically distinct conditions. While existing query-expansion methods improve query representation to mitigate ambiguity, they typically focus on enriching target-relevant semantics without an explicit mechanism to selectively suppress specific, clinically plausible hard negatives. This leaves the system prone to retrieving plausible mimics that overshadow the actual diagnosis, particularly when such mimics are dominant within the corpus. We propose Contrastive Hypothesis Retrieval (CHR), a framework inspired by the process of clinical differential diagnosis. CHR generates a target hypothesis $H^+$ for the likely correct answer and a mimic hypothesis $H^-$ for the most plausible incorrect alternative, then scores documents by promoting $H^+$-aligned evidence while penalizing $H^-$-aligned content. Across three medical QA benchmarks and three answer generators, CHR outperforms all five baselines in every configuration, with improvements of up to 10.4 percentage points over the next-best method. On the $n=587$ pooled cases where CHR answers correctly while embedded hypothetical-document query expansion does not, 85.2% have no shared documents between the top-5 retrieval lists of CHR and of that baseline, consistent with substantive retrieval redirection rather than light re-ranking of the same candidates. By explicitly modeling what to avoid alongside what to find, CHR bridges clinical reasoning with retrieval mechanism design and offers a practical path to reducing hard-negative contamination in medical RAG systems.

Retrieval-Augmented Generation (RAG) enhances the factuality of Large Language Models (LLMs) by incorporating retrieved documents and/or generated context. However, LLMs often exhibit a stylistic bias when presented with mixed contexts, favoring fluent but hallucinated generated content over factually grounded yet disorganized retrieved evidence. This phenomenon reveals that the utility of retrieved information is bottlenecked by its presentation. To bridge this gap, we propose QREAM, a style-controlled rewriter that aligns retrieved documents with a question-oriented style while preserving facts, better for LLM readers to utilize. Our framework consists of two stages: (1) QREAM-ICL, which uses stylistic seeds to guide iterative rewriting exploration; and (2) QREAM-FT, a lightweight student model distilled from denoised ICL outputs. QREAM-FT employs dual-criteria rejection sampling, filtering based on answer correctness and factual consistency to ensure high-quality supervision. QREAM seamlessly integrates into existing RAG pipelines as a plug-and-play module. Experiments demonstrate that QREAM consistently enhances advanced RAG pipelines, yielding up to 8% relative improvement with negligible latency overhead, effectively balancing question relevance with factual grounding.

Large Language Models (LLMs) have made query reformulation ubiquitous in modern retrieval and Retrieval-Augmented Generation (RAG) pipelines, enabling the generation of multiple semantically equivalent query variants. However, executing the full pipeline for every reformulation is computationally expensive, motivating selective execution: can we identify the best query variant before incurring downstream retrieval and generation costs? We investigate Query Performance Prediction (QPP) as a mechanism for variant selection across ad-hoc retrieval and end-to-end RAG. Unlike traditional QPP, which estimates query difficulty across topics, we study intra-topic discrimination - selecting the optimal reformulation among competing variants of the same information need. Through large-scale experiments on TREC-RAG using both sparse and dense retrievers, we evaluate pre- and post-retrieval predictors under correlation- and decision-based metrics. Our results reveal a systematic divergence between retrieval and generation objectives: variants that maximize ranking metrics such as nDCG often fail to produce the best generated answers, exposing a "utility gap" between retrieval relevance and generation fidelity. Nevertheless, QPP can reliably identify variants that improve end-to-end quality over the original query. Notably, lightweight pre-retrieval predictors frequently match or outperform more expensive post-retrieval methods, offering a latency-efficient approach to robust RAG.