Human-Like Lifelong Memory: A Neuroscience-Grounded Architecture for Infinite Interaction

Long-term memory is a critical challenge for Large Language Model agents, as fixed context windows cannot preserve coherence across extended interactions. Existing memory systems represent conversation history as unstructured embedding vectors, retrieving information through semantic similarity. This paradigm fails to capture the associative structure of human memory, wherein related experiences progressively strengthen interconnections through repeated co-activation. Inspired by cognitive neuroscience, we identify three mechanisms central to biological memory: association, consolidation, and spreading activation, which remain largely absent in current research. To bridge this gap, we propose HeLa-Mem, a bio-inspired memory architecture that models memory as a dynamic graph with Hebbian learning dynamics. HeLa-Mem employs a dual-level organization: (1) an episodic memory graph that evolves through co-activation patterns, and (2) a semantic memory store populated via Hebbian Distillation, wherein a Reflective Agent identifies densely connected memory hubs and distills them into structured, reusable semantic knowledge. This dual-path design leverages both semantic similarity and learned associations, mirroring the episodic-semantic distinction in human cognition. Experiments on LoCoMo demonstrate superior performance across four question categories while using significantly fewer context tokens. Code is available on GitHub: https://github.com/ReinerBRO/HeLa-Mem

We present SCM (Sleep-Consolidated Memory), a research preview of a memory architecture for large language models that draws on neuroscientific principles to address a fundamental limitation in current systems: the absence of persistent, structured, and biologically plausible memory. Existing approaches rely on truncating context windows, growing vector databases without bound, or tiered storage systems that lack consolidation and forgetting mechanisms. SCM implements five core components inspired by human memory: a limited-capacity working memory, multi-dimensional importance tagging, offline sleep-stage consolidation with distinct NREM and REM phases, intentional value-based forgetting, and a computational self-model enabling introspection. Across a standardized benchmark suite of eight tests, the prototype achieves perfect recall accuracy over ten-turn conversations while reducing memory noise by 90.9% through adaptive forgetting. Memory search latency remains below one millisecond even with hundreds of stored concepts. This work establishes the architectural foundations for memory systems that consolidate, prioritize, and forget, offering a testable platform for advancing LLM memory research.

Current LLM agents lack principled mechanisms for managing persistent memory across long interaction horizons. We present a biologically-grounded memory architecture comprising six cognitive mechanisms: (1) sleep-phase consolidation, (2) interference-based forgetting, (3) engram maturation, (4) reconsolidation upon retrieval, (5) entity knowledge graphs, and (6) hybrid multi-cue retrieval. Each mechanism addresses a specific failure mode of naive memory accumulation. We introduce a synthetic calibration methodology that derives all pipeline thresholds without benchmark data exposure, eliminating a common source of evaluation leakage. We evaluate on two benchmarks. First, a VSCode issue-tracking dataset (13K issues, 120K events) where deduplication-based consolidation achieves 97.2% retention precision with 58% store reduction (+21.8 pp over baseline). Second, the LongMemEval personal-chat benchmark where we conduct the first streaming M-tier evaluation (475 sessions, ~540K unique turns). At a 200K-token context budget, our pipeline matches raw retrieval accuracy (70.1% vs. 71.2%, overlapping 95% CI) while exposing a tunable accuracy/store-size operating curve. At S-tier scale (50 sessions), dedup-based consolidation yields a +13.3 pp improvement in preference recall.