Organizations: Vanderbilt University Medical Center, Nashville, TN, USA · Vanderbilt University, Nashville, TN, USA · Lirio, Knoxville, TN, USA · Virginia Tech, Blacksburg, VA, USA
Mental health concerns are often expressed outside clinical settings, including in high-distress help seeking, where safety-critical guidance may be needed. Consumer health informatics systems increasingly incorporate large language models (LLMs) for mental health question answering, yet many evaluations underrepresent narrative, high-distress inquiries. We introduce UTCO (User, Topic, Context, Tone), a prompt construction framework that represents an inquiry as four controllable elements for systematic stress testing. Using 2,075 UTCO-generated prompts, we evaluated Llama 3.3 and annotated hallucinations (fabricated or incorrect clinical content) and omissions (missing clinically necessary or safety-critical guidance). Hallucinations occurred in 6.5% of responses and omissions in 13.2%, with omissions concentrated in crisis and suicidal ideation prompts. Across regression, element-specific matching, and similarity-matched comparisons, failures were most consistently associated with context and tone, while user-background indicators showed no systematic differences after balancing. These findings support evaluating omissions as a primary safety outcome and moving beyond static benchmark question sets.
Figures & tables
Clinical topic domain
Total N
Hallucination rate
Omission rate
Medication-Specific Issues
174
10.9% (19)
13.2% (23)
Professional Care Navigation
155
9.7% (15)
10.3% (16)
Anxiety Experience and Management
300
8.3% (25)
14.0% (42)
Clinical Depression Experience and Management
348
7.5% (26)
18.7% (65)
Social & Relationship Dynamics
179
7.3% (13)
7.3% (13)
Treatment Approaches
272
6.6% (18)
9.2% (25)
Table 1: Prevalence of hallucinations and omissions by clinical topic domain ( N=2,075 ).
Figure 1: SHAP summary plots for the gradient-boosted tree models predicting hallucination (a) and omission (b). Features are ordered by overall contribution magnitude across inquiries.
Figure 2: Topic-stratified linguistic trigger profiles (descriptive). Heatmap of case-level mean LLM-judge severity scores (0 to 3) across topic domains. Topic-level summaries are descriptive and may be unstable in sparsely represented domains.
Linguistic Dimension (0–3)
Hallucination (n=61)
Omission (n=66)
Ambiguity / Underspecification
2.77±0.37
2.67±0.45
Missing Clinical Constraints
2.65±0.44
2.26±0.58
Emotional Load / Crisis Cues
2.00±0.76
2.46±0.73
Multi-intent / Scope Creep
1.57±0.75
1.46±0.80
Temporal Confusion
0.76±0.56
0.89±0.58
Logical Contradiction
0.03±0.13
0.15±0.40
Table 2: Linguistic taxonomy severity by failure mode (case-level). Scores (0 to 3) adjudicated by a blinded judge across up to K=10 neighbors. Values are reported as mean ± SD.
As LLM-powered chatbots are increasingly deployed in mental health services, detecting hallucinations and omissions has become critical for user safety. However, state-of-the-art LLM-as-a-judge methods often fail in high-risk healthcare contexts, where subtle errors can have serious consequences. We show that leading LLM judges achieve only 52% accuracy on mental health counseling data, with some hallucination detection approaches exhibiting near-zero recall. We identify the root cause as LLMs' inability to capture nuanced linguistic and therapeutic patterns recognized by domain experts. To address this, we propose a framework that integrates human expertise with LLMs to extract interpretable, domain-informed features across five analytical dimensions: logical consistency, entity verification, factual accuracy, linguistic uncertainty, and professional appropriateness. Experiments on a public mental health dataset and a new human-annotated dataset show that traditional machine learning models trained on these features achieve 0.717 F1 on our custom dataset and 0.849 F1 on a public benchmark for hallucination detection, with 0.59-0.64 F1 for omission detection across both datasets. Our results demonstrate that combining domain expertise with automated methods yields more reliable and transparent evaluation than black-box LLM judging in high-stakes mental health applications.
Khizar Hussain, Bradley A. Malin, Zhijun Yin +2
Virginia Tech, Blacksburg, VA, USA · Vanderbilt University Medical Center, Nashville, TN, USA
Large language models (LLMs) deployed in mental-health contexts can be evaluated for safety failures, but the resulting judgments are often difficult to inspect or explain. Common approaches to improving safety rely on prompt engineering, LLM-as-a-Judge, and Constitutional AI. In this work, we describe a clinician-led alternative in which two clinicians define, finalize, and adjudicate the four safety checks of a rule base, which is formally verified for internal consistency and applied as a guardrail over LLM outputs. Here and in the title, clinician-led refers to this rule base, not to the fact extractor or the uncertainty default, which are ours. Every verdict of the resulting verification layer is recomputable from a named rule and sixteen facts. Against an LLM judge matched in model, revision, quantization, rule text, and decoding but without the layer's computed 988/911 fact, the largest disagreement class, the satisfied-rule class, is structured: the Llama-3.3-70B judge, on its primary prompt, demands a crisis resource from 55 of the 65 replies (84.6%) that already contain one, while the same model, asked as a fact extractor, reports a recognized resource present on 54 of the 55. The verification layer never raises that demand, by construction. We report with equal prominence where this judge is stronger: fewer false crisis alarms on the one reference-scored check. We also report the measured cost (a specification revision raised block-class outcomes on held-out boundary prompts of an over-refusal benchmark from 6.0% to 16.0%, chiefly by changing fact extraction), the clinicians' decision to keep our uncertainty default, and the analysis of the result. The contribution is not a safer verdict. It is a guardrail whose disagreements with the judge localize to named rules and facts and whose measured costs trace to named facts and the uncertainty default.
Chenhan Lyu, Kit Wislocki, Sarah Elizabeth Stoeckl +2
LLM chatbots increasingly serve as a first source of support for people in psychological distress, including those whose distress is entangled with delusional beliefs. Prior work on LLM mental-health safety largely evaluates general therapeutic quality or single-turn crisis detection, leaving unclear how models behave when distress is intertwined with delusion over sustained conversations. We address this gap with matched multi-turn simulations, across clinically grounded personas and six LLMs, that pair each delusional conversation with a distress-only control to isolate the effect of delusional framing. This reveals a recognition-intervention gap: models detect distress at comparable rates regardless of framing, yet sharply fail to act on it once distress is embedded in delusion, with safety interventions suppressed by up to 4.5x. The failure tracks accumulated acceptance of the user's premises rather than emotional validation. Worse, the intuitive fix of prompting models to assess user distress backfires under delusional framing; only delusion-aware prompting with explicit response guidance closes the gap, and even this depends on a delusion classifier that is itself unreliable on the most vulnerable models. Safe deployment therefore requires treating delusional framing as a distinct risk signal that overrides conversational accommodation.
Andrew Aquilina, Chetna Nihalani, Vasudha Varadarajan +3
University of Pittsburgh · Carnegie Mellon University · Fordham University