Cross-Domain Vessel Segmentation via Latent Similarity Mining and Iterative Co-Optimization

Convolutional neural networks (CNNs) have achieved exciting performance in joint segmentation of optic disc and optic cup on single-institution datasets. However, their clinical translation is hindered by two major challenges: limited availability of large-scale, high-quality annotations and performance degradation caused by domain shift during deployment across heterogeneous imaging protocols and acquisition platforms. While unsupervised domain adaptation (UDA) provides a way to mitigate these limitations, most existing approaches do not address cross-domain interference and intra-domain generalization within a unified framework. In this paper, we present the Dual-Domain Synergy UDA (DDS-UDA), a novel UDA framework that comprises two key modules. First, a bi-directional cross-domain consistency regularization module is enforced to mitigate cross-domain interference through feature-level semantic information exchange guided by a coarse-to-fine dynamic mask generator, suppressing noise propagation while preserving structural coherence. Second, a frequency-driven intra-domain pseudo label learning module is used to enhance intra-domain generalization by synthesizing spectral amplitude-mixed supervision signals, which ensures high-fidelity feature alignment across domains. Implemented within a teacher-student architecture, DDS-UDA disentangles domain-specific biases from domain-invariant feature-level representations, thereby achieving robust adaptation to heterogeneous imaging environments. We conduct a comprehensive evaluation of our proposed method on two multi-domain fundus image datasets, demonstrating that it outperforms several existing UDA based methods and therefore providing an effective way for optic disc and optic cup segmentation.

Accurate retinal vessel segmentation requires features that capture vascular geometry while preserving information for fine-scale reconstruction. We propose CGDD-Net, a context-guided dynamic detail modeling network that connects adaptive feature extraction to a shared decoder pathway. Context-Guided Scale-Adaptive Deformable Encoding (CSDE) combines fixed-grid convolution with deformable local attention to capture vascular patterns at multiple spatial extents. Spatially Adaptive Multi-Kernel Gating (SAMG) selects receptive-field responses at each location. Dynamic Cross-Scale Detail Fusion (DCDF) aligns the gated intermediate features and compresses them into an eight-channel representation, which is reused at three decoder resolutions together with selected encoder skips. This design consolidates intermediate information before decoding instead of transferring each middle-stage feature through a separate direct skip. On DRIVE, CHASE_DB1, STARE, and HRF, CGDD-Net achieves AUC values of 0.9824, 0.9938, 0.9895, and 0.9874, with F1 scores of 0.8323, 0.8102, 0.8510, and 0.8157, respectively. The complete model contains 1.96 million trainable parameters. In cumulative ablations, the full model improves F1 over the internal baseline by 2.48, 0.61, and 3.49 percentage points on DRIVE, CHASE_DB1, and STARE. Twelve directed cross-dataset experiments further characterize transfer without target-domain adaptation. The results support shared intermediate detail delivery as an effective, parameter-compact architecture for retinal vessel segmentation. Code is available at https://github.com/lixincheng-xcl/CGDD-Net.

Retinal vessel segmentation in multi-domain deployment requires a source model to adapt to domains that differ in imaging conditions and annotation conventions. Conventional parameter-efficient fine-tuning reduces target-specific storage, but its highly restricted adaptation subspace can be insufficient for reconstructing thin, connected vascular structures. We therefore ask how target-specific capacity should be allocated so that topology-aware supervision remains effective under a strict per-domain parameter budget. Based on this principle, we propose TAPDecoderFT, a topology-responsive, role-structured adaptation framework. Specifically, TAPDecoderFT shares a fixed source parameter state across deployment domains, uses low-rank residuals for target-specific private/fusion feature mixing, and retains a trainable dense-reconstruction path comprising the decoder, output head, and refinement module. To promote structurally faithful predictions, the compact target state is jointly optimized with a region-overlap and topology-aware objective that encourages centerline continuity and thin-branch recovery. It improves both DSC and clDice over GenericLoRA-r4 and narrow TAP-r4 in all six directions and is comparable to full fine-tuning.