Self-Supervised Super-Resolution for Sentinel-5P Hyperspectral Images

Hyperspectral super-resolution (HSR) reconstructs a high-spatial-resolution hyperspectral image by fusing a low-resolution hyperspectral image (LR-HSI) with a high-resolution multispectral image (HR-MSI). In the absence of real-world paired data, HSR methods are evaluated almost exclusively on synthetic experiments derived from hyperspectral datasets through Wald's protocol. Despite the protocol's widespread adoption, its practical implementation varies markedly across research works, typically relying on a single (usually Gaussian) or very few point spread functions (PSFs), one or two spectral response functions (SRFs), and a couple of spatial downsampling factors. As a result, reported performance figures are difficult to compare across the literature, in addition to being often difficult to reproduce; furthermore, they may not generalize across realistic sensing conditions. We introduce HyperBench, a unified and extensible framework that standardizes synthetic experimentation for HSR. HyperBench supports diverse degradation configurations spanning ten PSFs, four SRFs derived from operational multispectral sensors, configurable spatial downsampling factors, and matched additive white Gaussian noise; its goal is to automate large-scale evaluation and structured logging. By decoupling model development from experimental design, the framework enables reproducible, apples-to-apples cross-method comparison with minimal friction. We use HyperBench to evaluate six recently proposed HSR methods across a 70-configuration sweep on four widely used hyperspectral scenes and observe that the inter-method PSNR spread widens from approximately 5 dB on the easiest PSF to over 13 dB on the hardest - a fragility that is structurally invisible to the prevailing single-configuration evaluation protocol. HyperBench code is available at https://github.com/ritikgshah/HyperBench .

Hyperspectral imaging is a powerful bioimaging tool which can uncover novel insights, thanks to its sensitivity to the intrinsic properties of materials. However, this enhanced contrast comes at the cost of system complexity, constrained by an inherent trade-off between spatial, spectral, and temporal resolution. To overcome this limitation, we present a self-supervised deep learning-based approach that restores and enhances pixel resolution post-acquisition without requiring external training data beyond the images to be restored. Fine-tuned using metrics aligned with the imaging model, our physics-aware method achieves a 16$\times$ pixel super-resolution enhancement and a 12$\times$ imaging speedup without the need of additional training data for transfer learning. Applied to both synthetic and experimental data from five different sample types, including healthy and diseased tissues, we demonstrate that the model preserves biological integrity, as we did not detect systematic loss of biological features or biologically consequential hallucinations in tested datasets. We also concretely demonstrate the model's ability to reveal disease-associated metabolic changes that would otherwise remain undetectable. Furthermore, we provide physical insights into the model's inner workings, paving the way for future refinements that could potentially reveal novel high resolution features in an explainable manner. All methods are available as open-source software on GitHub.

Hyperspectral imaging provides rich spectral information for quantitative remote sensing, yet hyperspectral sensors remain costly and thus unavailable in many UAV deployments. Spectral super-resolution (SSR) seeks to reconstruct hyperspectral images (HSIs) from multispectral images (MSIs). Most existing SSR methods assume a fixed and known spectral response function (SRF) and are therefore limited to single-sensor settings. In practical cross-sensor scenarios, the spectral degradation from HSI to MSI is unknown and varies with sensor characteristics and scene content, which renders HSI reconstruction ill-posed. This paper proposes a physics-guided deep unfolding network, termed PGU-Net, to address blind cross-sensor SSR by jointly estimating the HSI and a learnable spectral transformation function (STF). PGU-Net unrolls an alternating optimization procedure into an end-to-end trainable architecture with stages, where each stage sequentially updates the HSI and the STF. Both modules combine learnable proximal networks with differentiable closed-form solvers, enabling physical interpretability while retaining strong representation capacity. Experiments on benchmark datasets (CAVE and NTIRE 2022) with multiple SRFs demonstrate accurate recovery of the STF (degradation operator) and improved reconstruction performance over state-of-the-art SSR methods. Furthermore, evaluations on a real UAV cross-sensor dataset (Headwall Nano HSI and DJI P4 Multispectral MSI) verify the effectiveness and robustness of PGU-Net under truly blind conditions, and suggest that the estimated STF may exhibit land-cover-related differences.