BioGraphletQA: Knowledge-Anchored Generation of Complex QA Datasets

Evaluating large language models (LLMs) in the biomedical domain requires benchmarks that can distinguish reasoning from pattern matching and remain discriminative as model capabilities improve. Existing biomedical question answering (QA) benchmarks are limited in this respect. Multiple-choice formats can allow models to succeed through answer elimination rather than inference, while widely circulated exam-style datasets are increasingly vulnerable to performance saturation and training data contamination. Multi-hop reasoning, defined as the ability to integrate information across multiple sources to derive an answer, is central to clinically meaningful tasks such as diagnostic support, literature-based discovery, and hypothesis generation, yet remains underrepresented in current biomedical QA benchmarks. MedHopQA is a disease-centered multi-hop reasoning benchmark consisting of 1,000 expert-curated question-answer pairs introduced as a shared task at BioCreative IX. Each question requires synthesis of information across two distinct Wikipedia articles, and answers are provided in an open-ended free-text format. Gold annotations are augmented with ontology-grounded synonym sets from MONDO, NCBI Gene, and NCBI Taxonomy to support both lexical and concept-level evaluation. MedHopQA was constructed through a structured process combining human annotation, triage, iterative verification, and LLM-as-a-judge validation. To reduce leaderboard gaming and contamination risk, the 1,000 scored questions are embedded within a publicly downloadable set of 10,000 questions, with answers withheld, on a CodaBench leaderboard. MedHopQA provides both a benchmark and a reusable framework for constructing future biomedical QA datasets that prioritize compositional reasoning, saturation resistance, and contamination resistance as core design constraints.

While modern question answering (QA) systems excel on clean, schema-aligned corpora, real-world knowledge is rarely so neatly packaged. Answering questions over enterprise and scientific data lakes requires systems to navigate heterogeneous, weakly structured collections of tables, passages, and linked metadata. Current benchmarks abstract away this noisy discovery process, failing to evaluate end-to-end performance. To bridge this gap, we introduce LakeQuest, a human-validated benchmark of 9,846 QA pairs designed to evaluate the end-to-end retrieve-and-synthesize pipeline over realistic data lakes. LakeQuest spans three diverse domains (AI/ML metadata, retail banking, and multimodal biomedical drug information) and pairs every question with exact, modality-aware evidence pointers. By isolating source discovery from cross-modal synthesis, LakeQuest exposes critical failure modes in modern QA systems. Our baseline evaluations, including standard Retrieval-Augmented Generation (RAG) and agentic tool-use methods, reveal that high-quality retrieval does not guarantee correct reasoning. Systems consistently struggle with relation chaining in metadata graphs, policy grounding in bank ledgers, and joint tabular QA in biomedical contexts, highlighting the need for robust discovery and faithful cross-file composition mechanisms in future agentic QA systems.

Biomedical question answering (QA) increasingly requires reasoning over interacting entities, where supporting evidence is scattered across biomedical knowledge graphs, literature documents, and web-accessible resources. However, existing biomedical QA benchmarks mainly focus on exam-style knowledge, literature comprehension, or short-range multi-hop inference, leaving source-conditioned graph reasoning and evidence topology construction underexplored. To fill this gap, we introduce BioMedHop, a multi-source graph-grounded benchmark for evaluating biomedical reasoning over structured evidence topologies. BioMedHop contains 10,045 instances across KG, document, web, and hybrid evidence settings, covering shared-neighbor matching, intersection reasoning, path-based reasoning, and counting, with option-based, open-ended, and numeric count renderings. To support this benchmark, we further propose BioWeave, a source-aware reasoning framework that retrieves biomedical KG paths, gathers supporting clues from documents and web sources, assembles them into a unified evidence graph, and verifies answers through entity-level evidence support. Comprehensive experiments show that BioWeave achieves the best overall performance among compared methods on BioMedHop, outperforming the strong hybrid baseline ToG-2 by 10.5% in the overall average. Moreover, BioWeave consistently improves different LLM backbones and enables smaller models, such as Qwen3-4B, to achieve reasoning performance comparable to GPT-4-Turbo.