Spectral Dynamic Attention Network for Hyperspectral Image Super-Resolution

Hyperspectral imaging is a powerful bioimaging tool which can uncover novel insights, thanks to its sensitivity to the intrinsic properties of materials. However, this enhanced contrast comes at the cost of system complexity, constrained by an inherent trade-off between spatial, spectral, and temporal resolution. To overcome this limitation, we present a self-supervised deep learning-based approach that restores and enhances pixel resolution post-acquisition without requiring external training data beyond the images to be restored. Fine-tuned using metrics aligned with the imaging model, our physics-aware method achieves a 16$\times$ pixel super-resolution enhancement and a 12$\times$ imaging speedup without the need of additional training data for transfer learning. Applied to both synthetic and experimental data from five different sample types, including healthy and diseased tissues, we demonstrate that the model preserves biological integrity, as we did not detect systematic loss of biological features or biologically consequential hallucinations in tested datasets. We also concretely demonstrate the model's ability to reveal disease-associated metabolic changes that would otherwise remain undetectable. Furthermore, we provide physical insights into the model's inner workings, paving the way for future refinements that could potentially reveal novel high resolution features in an explainable manner. All methods are available as open-source software on GitHub.

Hyperspectral super-resolution (HSR) reconstructs a high-spatial-resolution hyperspectral image by fusing a low-resolution hyperspectral image (LR-HSI) with a high-resolution multispectral image (HR-MSI). In the absence of real-world paired data, HSR methods are evaluated almost exclusively on synthetic experiments derived from hyperspectral datasets through Wald's protocol. Despite the protocol's widespread adoption, its practical implementation varies markedly across research works, typically relying on a single (usually Gaussian) or very few point spread functions (PSFs), one or two spectral response functions (SRFs), and a couple of spatial downsampling factors. As a result, reported performance figures are difficult to compare across the literature, in addition to being often difficult to reproduce; furthermore, they may not generalize across realistic sensing conditions. We introduce HyperBench, a unified and extensible framework that standardizes synthetic experimentation for HSR. HyperBench supports diverse degradation configurations spanning ten PSFs, four SRFs derived from operational multispectral sensors, configurable spatial downsampling factors, and matched additive white Gaussian noise; its goal is to automate large-scale evaluation and structured logging. By decoupling model development from experimental design, the framework enables reproducible, apples-to-apples cross-method comparison with minimal friction. We use HyperBench to evaluate six recently proposed HSR methods across a 70-configuration sweep on four widely used hyperspectral scenes and observe that the inter-method PSNR spread widens from approximately 5 dB on the easiest PSF to over 13 dB on the hardest - a fragility that is structurally invisible to the prevailing single-configuration evaluation protocol. HyperBench code is available at https://github.com/ritikgshah/HyperBench .

Hyperspectral image super-resolution aims to reconstruct high-resolution imagery while preserving dense spectral information. Recently, Mamba-based models have shown promising potential for this task by capturing long-range dependencies with linear computational complexity. Nevertheless, their causal sequence modeling requires two-dimensional hyperspectral features to be unfolded along predefined scanning orders, which disrupts spatial adjacency and restricts the effective propagation of contextual information. Moreover, state-space parameterization of existing models is predominantly derived from generic learned representations, without explicit alignment with the intrinsic characteristics of the hyperspectral image. To address this issue, we propose an Unmixing-derived Spectral and Structural Prompting Mamba framework, termed USP-Mamba, which adapts Mamba state evolution through composition-aware spectral priors and image-dependent structural prompts. Specifically, an unmixing-informed spectral prompt captures the global material composition of the input image and provides persistent conditioning throughout reconstruction. Injected into the Mamba sequence and progressively adapted across layers, it steers state evolution toward composition-consistent reconstruction. We introduce feature-level structural prompts comprising spatial and frequency components to provide image-dependent local guidance. The spatial prompt promotes structure-sensitive state encoding for local detail preservation, while the frequency prompt enables region-adaptive transitions between homogeneous regions and high-frequency details. Finally, complementary Hilbert and Semantic-Guided Neighboring scans preserve spatial continuity and strengthen non-local semantic dependency modeling. Extensive experiments on different datasets demonstrate that the proposed method consistently outperforms representative approaches.