FQPDR: Federated Quantum Neural Network for Privacy-preserving Early Detection of Diabetic Retinopathy

Background and Objective: Automatic polyp segmentation supports computer-aided diagnosis and early colorectal cancer detec- tion. Centralized deep learning requires hospitals to share sensitive medical data, while federated learning preserves privacy but introduces high communication costs through repeated transmission of full-precision model parameters. We propose QFedPolyp, a communication- and inference-efficient federated learning framework for collaborative polyp segmentation. Methods: QFedPolyp combines quantization-aware training with low-precision model communication. Each hospital locally trains a lightweight U-Net on private data while simulating quantization during training. Clients transmit quantized model parameters to a central server, where they are reconstructed and aggregated using Federated Averaging. Evaluation is performed on Kvasir-SEG, CVC-ClinicVideoDB, PolypGen, and BKAI-IGH NeoPolyp. Results: Full-precision federated training achieves Dice scores of 0.910 on Kvasir-SEG and 0.930 on CVC-ClinicVideoDB. Uni- form 8-bit communication reduces transmission cost by approximately 4 times while preserving competitive segmentation accuracy. Quantized models also achieve up to 1.5 times faster inference than full-precision models. Conclusions: QFedPolyp enables privacy-preserving collaborative polyp segmentation with reduced communication overhead and faster inference. The resulting lightweight models are suitable for real-time clinical deployment.

Quantum federated learning enables distributed clients to train quantum neural networks without sharing local data, making it promising for privacy-aware intelligent services. Intelligent services in this context refer to privacy-sensitive distributed decision systems, such as fraud detection and genomic classification, where reliable and fair client-level learning is as important as the accuracy of the aggregate model. However, heterogeneous client data and noisy quantum optimization often cause unstable local updates, client drift, and unfair performance between clients. This paper proposes DUQFL-Prox, a drift-stable quantum federated learning framework based on deep-unfolded local optimization. Instead of using a fixed local optimizer, each client performs adaptive unfolded SPSA updates, while a proximal term keeps the local model close to the global model. A lightweight controller learns step-specific optimization parameters to improve post-aggregation performance. Experiments on financial fraud and genomic classification tasks show that DUQFL-Prox improves stability, generalization, and client fairness compared with standard QFL baselines. The results suggest that deep-unfolded quantum federated learning can support more reliable and fair intelligent services in heterogeneous distributed environments.

Federated Learning (FL) trains a global model across decentralized clients while preserving data privacy, but at scale it is vulnerable to malicious updates. Byzantine-resilient aggregation methods such as MultiKrum score gradients against their nearest neighbors and can miss malicious updates that preserve the statistical properties of honest ones. We propose a quantum annealing approach that reformulates client selection as a Quadratic Unconstrained Binary Optimization (QUBO) problem, encoding pairwise distances into a cost function solved by quantum annealers (QA). Unlike MultiKrum's greedy per-client scoring, the QUBO formulation jointly optimizes over all subsets to find the mutually closest group of $m$ clients. At small scale (15 clients), QUBO outperforms MultiKrum on the most challenging Byzantine attacks: e.g., Advanced LIE is detected with 95.11% accuracy versus 81.33% on MNIST and 97.78% versus 75.56% on CIFAR-10. QUBO fares poorly on simpler attacks where MultiKrum excels, so the two methods are complementary. QUBO quality also degrades as the number of clients grows. To address this, we introduce a MultiSignal ensemble that uses a dual-feature routing gate based on Euclidean and cosine Krum score gaps to classify attacks into four regimes and routes evasion attacks to a suspicion-penalized QUBO with agreement voting. At 100 clients on MNIST, MultiSignal achieves 95.3% average detection accuracy versus 91.8% for classical MultiKrum, with the largest gains on Sparse Lie (72.0% to 95.2%, +23.2 points) and Advanced Lie (80.4% to 85.2%, +4.8 points). These results show that QUBO-based quantum annealing with MultiSignal is a principled and scalable defense against the most challenging Byzantine strategies in federated learning.