Enhancing Blood Cells Classification using Hybrid Quantum Neural Networks

The integration of quantum machine learning with classical deep learning offers promising avenues for medical image analysis by mapping data into high-dimensional Hilbert spaces. However, effectively unifying these distinct paradigms remains challenging due to common optimization asymmetries. In this paper, a novel hybrid quantum-classical architecture for breast cancer diagnosis based on a dual-branch feature-extraction pipeline is proposed. Our framework extracts and unifies complementary representations from classical models and quantum circuits, exploring both trainable and deterministic (non-trainable) quantum paradigms. To integrate these embeddings, three progressive feature fusion strategies are introduced: Static Hybrid Fusion (SHF) for offline extraction, Dynamic Hybrid Fusion (DHF) for end-to-end co-adaptation, and a novel Temperature-Scaled Hybrid Fusion (TSHF). The TSHF strategy incorporates a learnable scalar, inspired by multimodal learning, that dynamically balances hybrid gradient dynamics and resolves optimization bottlenecks. Empirical validation on the BreastMNIST dataset confirms our hypothesis that unifying diverse feature representations creates a richer data context. The TSHF strategy, specifically when pairing a ResNet backbone with a trainable quantum circuit, achieved a peak accuracy of 87.82%, F1-score of 91.77%, and an AUC-ROC of 89.08%, outperforming purely classical baselines. These results demonstrate that the proposed hybrid framework improves classification accuracy and threshold reliability, providing a stable, high-performance architecture for the clinical deployment of quantum-enhanced diagnostic tools.

Numerous studies have analyzed the use of hybrid quantum-classical convolutional neural networks as a promising alternative to classical deep learning. However, network components on quantum hardware impose fundamental limitations, while the scalability of quantum circuits leads to trainability issues. In this work, we investigate whether small, classically-emulated quantum circuit components can play a meaningful role within complex models, offering an alternative to purely classical convolutional architectures. To this end, we present a systematic study of the effectiveness of a Hybrid Quantum-inspired Convolutional Neural Network (HQiCNN) compared with a parameter-matched classical Convolutional Neural Network (CNN) that differs only in an intermediate dense neural layer. Both models are evaluated on two real-world medical datasets while systematically varying the different hyperparameters, ensuring a fair model comparison that is both dataset and hyperparameter independent. The results show that no architecture consistently dominates the other: the HQiCNN achieves its largest gains in intermediate-data regimes, whereas the CNN reaches the highest accuracies for the largest training sets in both datasets. Furthermore, removing entanglement produces comparable performance while enabling substantially better scalability of quantum simulations, and richer observable sets become beneficial only when sufficient training data are available. Finally, we propose two SHAP-based explainability tools for comparing the predictions between both models, $|SHAP|$IoU and $EMD_{pos}$ metric, to demonstrate that both architectures consistently attend to anatomically plausible regions. Thus, we provide a comprehensive benchmark showing that, under certain conditions, hybrid quantum-inspired models are an alternative that can offer benefits in practical tasks such as medical image classification.

We propose a method to optimize the correlation among convolutional neural network (CNN) features that are used as inputs to quantum neural network (QNN) to enhance image classification accuracy. Unlike prior approaches that employ orthogonal decomposition as preprocessing, we intentionally introduce correlated features that are more physically compatible with QNN. This design leverages the QNN's inherent ability to exploit quantum entanglement for representing correlated states-an advantage unavailable to classical neural networks. We hypothesize that aligning feature correlations with the entanglement structure of QNN improves binary classification performance. Based on a mathematical derivation of QNN outputs, Monte Carlo simulations indicate that an average correlation between features of 0.5 yields optimal classification accuracy. To validate this finding, we evaluate a quantum-classical hybrid model on three tasks: CIFAR-10 (automobile vs. truck), Fashion-MNIST (shirt vs. coat), and radar micro-Doppler signatures (robotic dogs vs. non-robots). To regulate feature correlations, we introduce a correlation-regularization term on the outputs of the CNN, driving the off-diagonal entries of the feature correlation matrix toward a target constant. Across all datasets, inducing intermediate correlation consistently improved accuracy compared to low, high, or unregulated correlations, while also reducing classification accuracy variance. These results demonstrate that imposing moderate feature correlations-without modifying the quantum circuit-enhances classification accuracy and stability by aligning feature statistics with the QNN's entanglement structure. This study highlights the potential of QNN to surpass the performance of classical classifiers as more qubits become available.