ChainLearn: A Blockchain-Based Capacity-Aware Framework for Federated Ensemble Learning

Federated learning (FL) in healthcare faces pronounced heterogeneity and temporal concept drift across clinical centers, where evolving patient populations and care practices shift data distributions. Existing approaches rely on persistent global communication, incurring substantial bandwidth overhead while risking negative transfer from poorly aligned peers. We propose Adaptive Bayesian Partner Selection (ABPS), a peer-to-peer framework that governs who collaborates, when, and at what cost. Each center maintains a Beta-Bernoulli posterior over prospective peers' Shapley marginal utility, ranks candidates with an Upper Confidence Bound (UCB) criterion, and forms collaborations through a lightweight propose-reject mechanism, with the option to abstain from communication when no mutually beneficial partner exists. The framework admits a stochastic decision interpretation, yielding finite-sample concentration guarantees and O(kappa log T) regret in partner selection, along with conditions under which intentional isolation is optimal under negative transfer. Lightweight extensions (head personalization, bfloat16 quantized communication, and a tunable active-set size) further improve efficiency, and a goal-aware metadata filter enables institution-specific collaboration strategies. On binary in-hospital mortality prediction over the first 24 hours of an ICU stay, with 230 non-IID clinical centers drawn from MIMIC-IV, the full ABPS-X variant matches the strongest federated baseline (FedDyn, AUROC 0.758) at 0.09x the communication cost of FedAvg, with reduced variability. A diversity-driven configuration activates intentional isolation for a substantial fraction of centers. These results show that adaptive, utility-aware collaboration reduces communication without sacrificing accuracy when centers are numerous and small, offering a scalable paradigm for healthcare FL.

Federated learning (FL) enables collaborative model training without sharing raw patient data, but standard approaches such as FedAvg treat each client as a black box and provide no mechanism for isolating an adversarial contributor, auditing per-client influence, or honoring a departed participant's right to be forgotten. We present Fed-FBD (Federated Functional Block Diversification), a modular federated architecture that decomposes a ResNet backbone into six functional blocks (the stem, four residual groups, and the classification head) and maintains a warehouse of N color variants, each assembled from independently tracked and contributor-stamped blocks. Fed-FBD provides three capabilities absent in FedAvg: (i) architecturally guaranteed block-level isolation, so that an adversarial or mislabelled client cannot contaminate the clean colous; (ii) privacy-by-design, where membership inference advantage is already indistinguishable from chance before any privacy mechanism is applied; and (iii) surgical machine unlearning of a departed participant's contribution at sub-second cost and without retraining. Experiments on six MedMNIST-2D datasets, PathMNIST at 224x224, and CIFAR-10 show that Fed-FBD trades a modest 0.3%-3.1% IID accuracy gap on the adequately sized datasets for these guarantees, remains within 0.8%-4.0% of FedAvg at Dirichlet alpha=1.0 on three of four datasets, and confines all six adversarial attacks we study to the poisoned client's own blocks with at most +/-0.01 AUC drift on the clean colors.

Recent reviews find that the vast majority of published healthcare federated learning (FL) studies never reach real-world deployment. We developed an embedding-based FL pipeline for iron deficiency prediction from routine full blood count (FBC) data and deployed it across real institutional environments at Amsterdam University Medical Centre (AUMC) and NHS Blood and Transplant (NHSBT), two clinical environments that differ markedly in iron deficiency prevalence, ferritin distribution, and subject populations. A frozen domain-specific haematology foundation model, DeepCBC, performs site-local representation extraction, restricting federated training to a compact downstream classifier and substantially reducing recurrent communication relative to full-encoder federation. The two clinical datasets are structurally not independent and identically distributed (non-IID), with heterogeneity arising from distinct population differences rather than sampling artefacts. Runtime governance is enforced by FLA$^3$, a healthcare-oriented FL platform providing study-scoped execution, policy-based authorisation, and signed audit logging. Standard sample-size-weighted aggregation (FedAvg) reduced the area under the receiver operating characteristic curve (ROC-AUC) at both sites relative to local-only training, as the global update was biased towards the larger AUMC distribution. FedMAP, a personalised aggregation method, raised ROC-AUC from 0.9470 to 0.9594 at AUMC and from 0.8558 to 0.8671 at NHSBT relative to local-only training, achieving the highest macro ROC-AUC of 0.9133 and the best macro balanced accuracy overall. These results support personalised aggregation in clinical federations where client sample size and task relevance diverge substantially.