Security in the Fine-Tuning Lifecycle of Large Language Models: Threats, Defenses,Evaluation, and Future Directions

Current open-weight large language models (LLMs) are prone to malicious finetuning attacks, which could compromise the safety alignment of LLMs with only a few steps of supervised finetuning (SFT) on poisoned datasets. Existing alignment-stage defenses are primarily designed to defend against attacks that use parameter-efficient finetuning methods. However, they fail to defend against stronger attacks that use full-parameter finetuning. In this paper, we propose Patcher, a method inspired by adversarial training and bi-level optimization, to combat such attacks. Patcher strengthens the simulated attack by scaling up the optimization steps in the adversarial loop, thus forcing the defender to find model parameters that are insensitive to stronger attacks. Furthermore, we propose an efficient parallel algorithm to implement Patcher, decreasing the wall-clock time of training while preserving Patcher's performance. Extensive experiments show that Patcher substantially improves the model's robustness compared to vanilla SFT alignment, and transfers to diverse attack scenarios and model sizes. Code is available at https://github.com/haomingwen/patcher.

Large language models are no longer only text generators. They are increasingly embedded in retrieval pipelines, enterprise assistants, coding environments, robotic systems, security-operation workflows, and autonomous agents that can read private data, call tools, write files, execute code, and act across organizational boundaries. This shift changes the security problem: risks do not arise from the model weights alone, but from the full lifecycle and application stack through which data, prompts, model outputs, tools, memories, and user authority interact. This paper systematizes the literature on vulnerabilities in large language model systems through a lifecycle and application-stack lens. We organize attacks across eight stages: data collection, pretraining, post-training alignment, model packaging and supply chain, retrieval and memory, prompting and inference, tool/agent execution, and deployment/maintenance. For each stage, we analyze attacker capabilities, affected security objectives, representative attacks, practical risks, evaluation practices, and defenses. We further map LLM-specific vulnerabilities to confidentiality, integrity, availability, safety, privacy, fairness, accountability, and agency-control objectives. Unlike taxonomies that list isolated attack names, the proposed systematization emphasizes where trust boundaries fail, how untrusted data becomes executable instruction, how delegated authority amplifies model errors, and why point defenses rarely compose. We close with a research agenda for secure LLM systems, including compositional security, provenance-aware retrieval, tool-call containment, long-horizon agent evaluation, privacy-preserving adaptation, realistic red teaming, and deployment-grade incident response.

Recent defenses for safeguarding open-weight large language models (LLMs) are intended to prevent adversarial usage. Underlying these defenses is an assumption that new harmful behavior is learned through fine-tuning rather than elicited by jailbreaking the model. Yet, pretrained LLMs already encode substantial harmful knowledge across many domains, which raises an important question: can an adversary jailbreak safeguarded models, to achieve harmful usage without fine-tuning at all? In this paper, we show that open-weight safeguards are susceptible to simpler strategies that, despite being well known, have not been systematically evaluated against these safeguards. Specifically, we evaluate two low-cost attacks--abliteration and prefilling--that do not rely on gradient-based optimization. Across three harmfulness evaluation benchmarks (BeaverTails, HarmBench, and AdvBench), these attacks increase attack success rates against safeguarded open-weight models from below 10% to a range of 16%-96%. To mitigate this vulnerability, we introduce abliteration-resistant tuning (ART), which incorporates an abliteration-based objective into training. ART can be layered onto existing defenses and reduces the success rates of abliteration, prefilling, and their combination by 10%-20%. These findings indicate that the attack surface for open-weight models is broader than previously characterized, and that evaluations of safeguarding defenses should incorporate a more diverse set of attack strategies beyond adversarial fine-tuning.