CL-DMDF:Dynamic Multimodal Data Fusion Model Based on Contrastive Learning

Multimodal feature fusion can effectively capture complex patterns in real-world data by integrating complementary information from different modalities. However, in many applications, such as boiler combustion monitoring, equipment failure, inconsistent sensor sampling frequencies, and network delays often cause missing modalities and temporal asynchrony. These issues lead to incomplete and disorderly multimodal data. To address them, previous studies have proposed several data fusion methods that align cluster centers before fusion. However, these methods have two key limitations. First, they cannot guarantee accurate sample-level alignment of data pairs. Second, they do not address significant discrepancies in data sizes across different classes, which may affect subsequent fusion performance. To address these problems, we propose a dual-learning based penalized multi-align clustering model, named DLPMAC. The dual-learning mechanism enables the model to learn prior knowledge from each modality, including semantic and structural information. This helps preserve semantic consistency and structural similarity across modalities at both local and global levels. In addition, the penalized multi-align module performs multi-to-multi data alignment through a penalty mechanism. It allows one sample to form data pairs with different samples from other modalities, thereby improving data-pair alignment accuracy. The penalty mechanism also prevents data aggregation, avoiding the case where excessive samples are linked to a single sample. Experimental results demonstrate the effectiveness of DLPMAC in addressing data alignment and fusion challenges from both sampling and clustering perspectives.

Multimodal fusion learning (MFL) has shown great potential in the medical domain, where we are faced with disparate data modalities such as imaging, clinical records, and omics. However, existing MFL strategies face several major challenges. First, they struggle to capture complex cross-modal interactions effectively, which in turn limits performance improvements. Second, they incur high computational costs, restricting their applicability in resource-constrained healthcare AI applications. Finally, they are often designed and evaluated for narrow, fixed modality configurations (e.g., imaging-only, or specific pairs such as image and omics), which limits evidence of their adaptability and generalizability to broader collections of heterogeneous medical modalities. To address these challenges, we propose a novel MFL framework - Cascaded Unified Representation Learning for Efficient Fusion Network (CURE) - a lightweight and scalable framework that progressively integrates various modalities through a novel efficient Hybrid Geometry Aware Fusion layer (HyFuse), where each HyFuse layer is sequentially learned for each modality, making the framework adaptable and generalizable. Within HyFuse, an efficient residual convolution module captures rich multi-scale features to ensure cost-effective learning, while a hybrid-space aware attention mixer learns coarse-to-fine structural cues to better preserve cross-modal relationships. Complementary learnable late-fusion and shared information refinement modules are then employed to learn robust modality-order-invariant shared representations, which in turn yields consistent performance improvements. Extensive evaluations on 16 public datasets show that CURE outperforms leading multimodal fusion methods, boosting performance by up to 3.97% and lowering computational costs by up to 87.8%, ensuring more effective and reliable predictions.

This paper addresses the missing-modality challenge in multi-modal learning by introducing Unsupervised Learning for Missing Modalities in Multi-Modal Learning (UL4M4), a flexible framework that imputes missing feature embeddings in a task-independent manner before supervised prediction. We propose modality-specific normalization and a novel partial-modality distance metric to enable fair clustering of incomplete observations, capturing cross-modal structures while preserving scale-invariance across varying dimensionalities and modality counts. Cluster centers from this unsupervised stage guide an iterative greedy imputation process for any missing modalities during training or inference, supporting arbitrary numbers of modalities and arbitrary missing patterns per sample. The imputation module is lightweight, uses frozen encoders, and decouples from the downstream task, allowing easy integration with any fusion/prediction architecture. Extensive experiments under diverse and highly incomplete regimes demonstrate UL4M4's robustness, achieving, to the best of our knowledge, the first consistent F1-Micro scores above 0.7 on challenging missing configurations even when more than 50% of modality slots are missing. Results are also stable across cluster sizes and significantly outperform state-of-the-art baselines. Code is available here: https://github.com/h-ismkhan/Multimodal-Learning-with-Missing-Modalities-via-Unsupervised-Learning.