Diffusion-weighted imaging (DWI) is used for whole-body cancer screening, but it typically requires a long acquisition time. When the scan time is reduced, the image quality often suffers, leading to increased noise in the scans. Magnitude reconstruction in DWI introduces signal-dependent Rician noise, which makes denoising more challenging for conventional convolution-based methods. To address this limitation, we propose a noise-aware attention-driven denoising framework that integrates hierarchical Swin Transformer window attention with transformer-based multi-dimensional gated refinement for DWI restoration. The model incorporates explicit noise-level conditioning and residual reconstruction to enable adaptive suppression of heteroscedastic noise across a wide range of corruption levels. Experimental evaluation on corrupted DWI scans demonstrates strong restoration performance. Our model achieves a mean PSNR of 33.69~dB and SSIM of 0.8539 across noise levels from 1% to 15%, while maintaining stable behavior under severe noise conditions. These results indicate that attention-guided contextual modeling combined with channel-adaptive refinement provides a robust and generalizable solution for DWI denoising.
High-resolution (HR) MRI acquisition is often hampered by scan time constraints, resulting in anisotropic or low-resolution scans (e.g., thick-slice FLAIR) that limit diagnostic accuracy. While deep learning-based super-resolution (SR) methods show promise, they often hallucinate anatomical details, which can compromise brain structural integrity. To mitigate this limitation, we introduce MR-DiffuSR, a Multi-Resolution Diffusion-based Super-Resolution framework that incorporates HR T1w structural image priors to guide the restoration of thick-slice FLAIR scans and operates in the 3D latent space. Our architecture introduces cross-modality structural swin-attention, which derives structural attention maps from the HR T1w and applies them to the low-resolution FLAIR latent features. This design disentangles anatomical structure from modality-specific contrast, effectively preventing hallucinations. Furthermore, we employ a mixed-scale degradation strategy, training the model on a continuum of downsampling factors to ensure robustness to varying slice thicknesses, while optimizing with a DINOv3-based perceptual loss to preserve high-frequency semantic details. Evaluated on the ADNI-4 dataset, MR-DiffuSR surpasses both CNN and 2D diffusion approaches, achieving an average PSNR of 32.46dB, SSIM of 0.97, and LPIPS of 0.07 across all downsampling factors. In downstream white matter hyperintensity segmentation, our model demonstrates exceptional robustness. While baseline performance collapses at 10x down-sampling (Dice: 0.51), MR-DiffuSR maintains a Dice score of 0.63, preserving utility even at 7mm equivalent slice thickness.
While deep learning-based denoising has become widely adopted in low-dose CT, conventional models use generic architectures designed for natural images, failing to account for non-stationary and spatially correlated CT noise characteristics. To address this, we propose an Efficient Noise COntext-aware REpresentation (ENCORE) framework that explicitly leverages CT noise characteristics and anatomical features. First, we reformulate the noise synthesis procedure based on a realistic noise distribution beyond the conventional Gaussian approximation, establishing a rigorous foundation for training pair generation. Next, we extract local noise power and correlation contexts to guide the denoising process. To fully leverage the potential of noise context, we propose a FlyingConv module, which adaptively changes convolution weights for each local image region. Notably, our approach demonstrates substantial gains in both denoising quality and computational efficiency. Furthermore, manipulating the intensity of the noise context maps at inference time enables zero-shot conditional denoising, allowing for dynamic control over the output image texture. The entire pipeline is available at https://github.com/minwoo-yu/ENCORE.git
Denoising diffusion models are the dominant architecture for image generation, whereas most natural language generation and modeling are primarily handled by well-known transformer architectures employing attention mechanism. Here, we show that diffusion models also inherently use an attention mechanism very similar to that of transformers. Therefore, attention emerges as a universal machine learning principle, based on a general training objective. We also show similarities in basic functional principle of auto-encoders and attention-based models. These equivalences allows us to interchange these designs based on practical requirements. As an example, we can reformulate the diffusion framework to reduce the lengthy training process and computation-intensive image generation. Using this approach, a simplified algorithm is proposed for image generation which is based on attention mechanism. Results show that the attention-based implementation achieves comparable performance with significantly less effort and computational resources.