Self-Supervised Vision Transformers for CBCT-Based Detection of Temporomandibular Joint Osteoarthritis

Recent breakthroughs in self-supervised learning (SSL), such as the Latent-Euclidean Joint-Embedding Predictive Architecture (LeJEPA), alongside successes in integrating visual encoders with language models, have driven the demand for adaptable, high-capacity vision encoders in Computed Tomography (CT). In this work, we explore 2D slice-based architectures as a flexible alternative to native 3D models for processing volumetric CT data. Using the CT-RATE dataset, we trained DALE-CT (Depth-Aware Latent-Euclidean Computed Tomography), a 2D model family built entirely from scratch using LeJEPA, and compared its performance against a continually pre-trained DINOv2 baseline. To enhance representation quality, we developed a novel 3D depth-aware pre-training strategy anchored by dense auxiliary supervision from both automated anatomical masks and human-annotated abnormalities. Under linear probe evaluation with Multiple Instance Learning (MIL) for multi-abnormality detection, the frozen backbone of this dual-supervised model (DALE-CT-2S) achieves a Macro AUROC of 0.833. This performance demonstrates near-parity with state-of-the-art 3D vision-language models, achieved entirely from scratch with significantly less data and no textual supervision. To ensure reproducibility, all training code, evaluation scripts, and model weights have been made publicly available.

Vision foundation models (VFMs) such as DINO are pretrained for single-image representation, whereas remote sensing change detection requires reasoning over a bi-temporal pair. Existing VFM-based methods usually encode the two images independently and compare them only afterward, leaving the VFM backbone unaware of cross-temporal relations. To bridge this mismatch, we present AdaDINO, a pair-aware in-backbone adaptation framework that equips a frozen DINO encoder with bi-temporal interaction for efficient change detection. Its core component, Change-aware Gated Local Adaptation (CGLA), couples the two streams after selected frozen blocks and injects a shared temporal residual into them with opposite signs, enhancing genuine change responses while preserving the pair midpoint. Batch-Shared Chunk Selection (BSCS) further reduces feed-forward network (FFN) computation by retaining a batch-shared subset of channel chunks that can be executed as a compact dense FFN. A CGLA-Prior-Guided Refinement (CPGR) decoder reuses encoder-side change responses for coarse-to-fine prediction. Experiments on four remote sensing change detection benchmarks show that AdaDINO achieves competitive or superior performance against VFM-based baselines, with the largest gain on the category-agnostic SYSU-CD dataset. With 62.5% of the FFN hidden width removed, AdaDINO still achieves an F1 score of 85.29% on SYSU-CD while delivering a 1.41$\times$ throughput speedup. The code will be released.

Vision foundation models trained with self-supervised objectives achieve strong performance across diverse tasks and exhibit emergent object segmentation properties. However, their alignment with human object perception remains poorly understood. Here, we introduce a behavioral benchmark in which participants make same/different object judgments for dot pairs on naturalistic scenes, scaling up a classical psychophysics paradigm to over 1000 trials. We test a diverse set of vision models using a simple readout from their representations to predict subjects' reaction times. We observe a steady improvement across model generations, with both architecture and training objective contributing to alignment, and transformer-based models trained with the DINO self-supervised objective showing the strongest performance. To investigate the source of this improvement, we propose a novel metric to quantify the object-centric component of representations by measuring patch similarity within and between objects. Across models, stronger object-centric structure predicts human segmentation behavior more accurately. We further show that matching the Gram matrix of supervised transformer models, capturing similarity structure across image patches, with that of a self-supervised model through distillation improves their alignment with human behavior, converging with the prior finding that Gram anchoring improves DINOv3's feature quality. Together, these results demonstrate that self-supervised vision models capture object structure in a behaviorally human-like manner, and that Gram matrix structure plays a role in driving perceptual alignment.