cs.AIJun 26, 2026

Agent-Native Immune System: Architecture, Taxonomy, and Engineering

Authors: Bo Shen, Lifeng Chang, Tianyuan Wei, Yunpeng Li, Feng Shi, Yichen Han, Peijie Gao, Shiyi Kuang, +2 more

Abstract

The transition from static chat bots to autonomous agents--equipped with persistent memory, tool-use protocols, and multi-agent collaboration--has fundamentally expanded the AI threat landscape. Current defense mechanisms, such as perimeter security and training-time alignment, remain external to the agent's active reasoning loop. Consequently, they fall short: a fully aligned agent remains highly vulnerable to runtime hijacking via memory poisoning, tool-chain manipulation, or multi-agent protocol attacks. To address this critical gap, we introduce the Agent-Native Immune System (ANIS), the first biologically inspired, endogenous defense architecture embedded directly within the agent's cognitive loop. Our framework presents four primary contributions. First, we design a six-layer Immune Tower (L0-L5), distinctly incorporating Barrier Immunity (L1) as a non-cognitive, physical-and-logical isolation layer. Second, we establish a unified taxonomy of Agent Viruses and Agent Vaccines, formalizing the critical distinction between superficial non-parametric defenses and robust parametric vaccines. Third, we conceptualize the Harness Triad--Meta, Self, and Auto--a self-monitoring, meta-cognitive automation backbone that drives Continual Immune Learning (CIL), enabling vaccines to dynamically adapt to novel threats. Finally, we establish a rigorous theoretical demarcation between model alignment and agent immunity: while alignment provides a static "constitutional" value foundation during training, ANIS serves as the dynamic "law enforcement" mechanism during runtime. We conclude by framing open challenges for the field, including immune protocol standardization, novel evaluation metrics such as the Autoimmunity Rate (false-positive intervention rate), and the co-evolutionary dynamics between pathogens and vaccines within collective intelligence ecosystems.

Explore similar work

CardsList
Apr 27, 2026cs.CR

AgentWard: A Lifecycle Security Architecture for Autonomous AI Agents

Autonomous AI agents extend large language models into full runtime systems that load skills, ingest external content, maintain memory, plan multi-step actions, and invoke privileged tools. In such systems, security failures rarely remain confined to a single interface; instead, they can propagate across initialization, input processing, memory, decision-making, and execution, often becoming apparent only when harmful effects materialize in the environment. This paper presents AgentWard, a lifecycle-oriented, defense-in-depth architecture that systematically organizes protection across these five stages. AgentWard integrates stage-specific, heterogeneous controls with cross-layer coordination, enabling threats to be intercepted along their propagation paths while safeguarding critical assets. We detail the design rationale and architecture of five coordinated protection layers, and implement a plugin-native prototype on OpenClaw to demonstrate practical feasibility. This perspective provides a concrete blueprint for structuring runtime security controls, managing trust propagation, and enforcing execution containment in autonomous AI agents. Our code is available at https://github.com/FIND-Lab/AgentWard .
Yixiang Zhang, Xinhao Deng, Jiaqing Wu +3
Runtime EnforcementArtificial Intelligence RiskArtificial Intelligence AgentsCross-Layer Interactions
AskPDF
Apr 25, 2026cs.CR

A Systematic Survey of Security Threats and Defenses in LLM-Based AI Agents: A Layered Attack Surface Framework

Agentic AI systems introduce a security surface that is qualitatively different from that of stateless LLMs. They persist memory, invoke external tools, coordinate with peer agents, and operate across sessions, allowing attacks to emerge not only at the prompt interface but also through architectural state, delegated authority, and long-horizon interactions. Existing security taxonomies, however, primarily organize threats by attack type, such as prompt injection or jailbreaking, and therefore obscure where in the agentic stack a threat arises and over what timescale it manifests. We propose the Layered Attack Surface Model (\lasm), a structural taxonomy for agentic AI security. \lasm decomposes the agentic stack into seven layers -- Foundation, Cognitive, Memory, Tool Execution, Multi-Agent Coordination, Ecosystem, and Governance -- and augments them with a four-class temporality axis covering instantaneous, session-persistent, cross-session cumulative, and sub-session-stack threats. We use this 7×\times4 framework to analyze 116 papers from 2021--2026. The resulting map reveals that the upper layers of the agentic stack remain sharply under-explored, especially for long-horizon and stack-propagating threats; multiple documented attack regions have no corresponding defenses; and current benchmarks provide no coverage for cross-session or sub-session-stack failure modes. We further derive a cross-layer defense taxonomy, defense recipes for canonical attack classes, and a dependency DAG that separates near-term engineering gaps from fundamental research challenges. We release the per-paper coding, robustness scripts, and a reference Agent Bill of Materials schema to support reproducible analysis.
Kexin Chu
Threat ModelsArtificial Intelligence RiskProduction Agentic SystemsAttack SurfaceAgentic AI SystemsTaxonomy+1
AskPDF
Apr 27, 2026cs.CR

Poster: ClawdGo: Endogenous Security Awareness Training for Autonomous AI Agents

Autonomous AI agents deployed on platforms such as OpenClaw face prompt injection, memory poisoning, supply-chain attacks, and social engineering, yet existing defences address only the platform perimeter, leaving the agent's own threat judgement entirely untrained. We present ClawdGo, a framework for endogenous security awareness training: we teach the agent to recognise and reason about threats from the inside, at inference time, with no model modification. Four contributions are introduced: TLDT (Three-Layer Domain Taxonomy) organises 12 trainable dimensions across Self-Defence, Owner-Protection, and Enterprise-Security layers; ASAT (Autonomous Security Awareness Training) is a self-play loop where the agent alternates attacker, defender, and evaluator roles under weakest-first curriculum scheduling; CSMA (Cross-Session Memory Accumulation) compounds skill gains via a four-layer persistent memory architecture and Axiom Crystallisation Promotion (ACP); and SACP (Security Awareness Calibration Problem) formalises the precision-recall tradeoff introduced by endogenous training. Live experiments show weakest-first ASAT raises average TLDT score from 80.9 to 96.9 over 16 sessions, outperforming uniform-random scheduling by 6.5 points and covering 11 of 12 dimensions. CSMA retains the full gain across sessions; cold-start ablation recovers only 2.4 points, leaving a 13.6-point gap. E-mode generates 32 TLDT-conformant scenarios covering all 12 dimensions. SACP is observed when a heavily trained agent classifies a legitimate capability assessment as prompt injection (30/160).
Jiaqi Li, Yang Zhao, Bin Sun +3
Artificial Intelligence AgentsClaws
AskPDF