Organizations: School of Computing and Artificial Intelligence, Shanghai University of Finance and Economics · College of Computer Science and Artificial Intelligence, Fudan University · Independent Researcher · School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine and Pharmacology
Acquiring comprehensive cross-domain biomedical profiles is often costly and time-consuming, resulting in severe data scarcity in medical research. To address this challenge, we propose MedKGTab, a knowledge-injected framework specifically engineered for cross-domain feature expansion in tabular medical data. MedKGTab seeks to infer uncollected biomedical features from available ones by exploiting their inherent statistical dependencies and established medical correlations. By employing a row-column dual-attention mechanism, MedKGTab operates directly on raw structured tabular data, inherently capturing exact numerical distributions without the structural loss caused by tokenization. Crucially, MedKGTab integrates data-driven statistical priors with the SPOKE biomedical knowledge graph, achieving an optimal synergy between the data and knowledge channels. Within this synergy, the representations derived from the data channel are modulated by the injected biomedical knowledge, ensuring the final generated data are grounded in empirical medical research. Experimental results demonstrate that MedKGTab achieves high data fidelity and realistic data representation in cross-domain feature expansion. It outperforms both SOTA medical large models (e.g., Baichuan M3-plus) and specialized tabular models designed for medical data generation. Furthermore, MedKGTab consistently delivers superior performance across various data generation scenarios, whether inferring missing features within the same dataset or generalizing across different medical cohorts.
While vision-language models dominate medical representation learning, unstructured text lacks the dense, quantitative diagnostic phenotypes inherent in structured clinical tables. However, existing multimodal pre-training methods underutilize this potential due to semantic-agnostic designs that treat tabular inputs as flat vectors and employ unstable continuous regression objectives. To overcome this, we propose a novel semantic-aware framework explicitly modeling the intrinsic two-dimensional structure of tabular data. First, addressing the inter-feature hierarchy of varying diagnostic importance, we introduce Importance-Aware Adaptive Masking to construct a label-free curriculum prioritizing salient features. Second, addressing the intra-feature continuity-discreteness duality, we propose a Soft-Label Discretized Module that replaces unstable numerical regression with stable distribution matching, thereby mathematically preserving ordinal relationships. Extensive experiments across large-scale dermatology (SLICE-3D, HOP) and ophthalmology (EyePACS) datasets establish a new state-of-the-art (SOTA), demonstrating exceptional robustness and cross-domain generalizability.
Biomedical tables often combine thousands of measured variables with only tens or hundreds of labelled samples, a regime that is poorly represented in general-purpose tabular benchmarks. We introduce TabBench-Bio, a living and interactive benchmark of 43 biomedical datasets spanning multiple domains. Under a shared cross-validation protocol, we compare classical estimators, neural networks, and tabular foundation models across 28 feature-by-sample operating points. At the reference cell of 10,000 features and 100 training samples, RealTabPFN v2.5 has the highest point estimate, followed by Logistic Regression and TabDPT, whose point estimates are nearly identical. A paired bootstrap over the target pool separates RealTabPFN v2.5 from Logistic Regression by 145 Elo (95% interval [59, 232]). Tabular foundation models generally occupy the leading ranks, while the strongest configuration depends on the operating point and biomedical modality. The AutoML framework AutoGluon, using its one-hour "extreme" preset, is configured as a separate resource-intensive reference and is reported here at the reference cell. Fold-level predictions, run status, and deterministic aggregations make every reported result reproducible and reusable. We invite the community to contribute: TabBench-Bio is designed to grow, and we welcome submissions of new biomedical tabular datasets, particularly from underrepresented assays and clinical endpoints, for inclusion in future releases. The interactive leaderboard is available at: https://tabbench-bio.eu
Generating mixed-type tabular data requires jointly modeling diverse feature distributions and their complex cross-column dependencies. Variational flow matching handles distinct endpoints via factorized distributions, yet leaves feature-specific processing and cross-column interactions implicit within a shared backbone. We introduce Feature-wise Unified Specialization with cross-column Exchange (FUSE) to explicitly separate these roles. FUSE applies separate adaptive mixture modules to numerical and categorical features, allowing each feature to combine shared specialized subnetworks, while joint attention preserves information exchange across all columns. We also characterize the excess population risk from restricted conditioning contexts and bound the continuous Wasserstein generation error by endpoint-prediction risk. Comprehensive experiments on eight tabular datasets demonstrate that FUSE achieves strong and consistent performance across distributional fidelity and downstream utility metrics.