Sparse Autoencoders for Interpretable Out-of-Distribution Detection
Authors: Ayush Karmacharya, Luke Luschwitz, Lucia Romero, Yanan Niu, Joseph Campbell
Organizations: Purdue University · EPFL
Abstract
Reliable detection of out-of-distribution (OOD) samples is crucial for the safe deployment of machine learning models. Neural networks often produce overconfident predictions for inputs that deviate from their training data, leading to significant degradation in performance. While many OOD detection methods focus on the final output layer, they neglect the rich hierarchical information present in intermediate network layers. This paper introduces a novel approach that leverages sparse autoencoders (SAEs) to learn interpretable features from these intermediate activations. We find that in-distribution (ID) and OOD data activate distinct sets of these sparse features. We propose a new OOD score derived from the cosine similarity between the sparse feature activations of a test sample and the mean activations of ID classes. Our post-hoc detection method not only achieves state-of-the-art performance on standard OOD detection benchmarks, but yields interpretable insights into how distribution shift affects learned representations.
Deep neural networks have achieved remarkable performance across medical imaging tasks, yet their tendency to overgeneralize under distributional shifts poses a major obstacle to safe clinical deployment. Out-of-Distribution (OOD) detection methods aim to mitigate this risk, but most existing approaches rely on opaque internal signals with poorly understood semantic meaning, limiting trust in safety-critical settings. In this work, we propose an interpretable OOD detection framework that probes the stability of model predictions under class-conditioned semantic perturbations. Leveraging sparse autoencoders (SAEs), we learn class-specific concept vectors from in-distribution data that disentangle dense intermediate representations into sparse, semantically meaningful components. At inference, we perturb deeper-layer representations using the concept vectors associated with the model's predicted class and measure the class logits stability. We hypothesize that in-distribution samples exhibit low sensitivity to such perturbations, as their representations align with class-specific semantic directions, whereas OOD samples show amplified deviations due to representational misalignment. By framing OOD detection as a concept conditioned stability analysis, our approach provides both a discriminative OOD signal and an interpretable lens into the internal mechanisms driving model uncertainty, making it particularly suitable for high stakes medical applications.
Sparse Autoencoders (SAEs) have demonstrated significant success in interpreting Large Language Models (LLMs) by decomposing dense representations into sparse, semantic components. However, their potential for analyzing Vision Transformers (ViTs) remains largely under-explored. In this work, we present the first application of SAEs to the ViT [CLS] token for out-of-distribution (OOD) detection, addressing the limitation of existing methods that rely on entangled feature representations. We propose a novel framework utilizing a Top-k SAE to disentangle the dense [CLS] features into a structured latent space. Through this analysis, we reveal that in-distribution (ID) data exhibits consistent, class-specific activation patterns, which we formalize as Class Activation Profiles (CAPs). Our study uncovers a key structural invariant: while ID samples preserve a stable pattern within CAPs, OOD samples systematically disrupt this structure. Leveraging this insight, we introduce a scoring function based on the divergence of core energy profiles to quantify the deviation from ideal activation profiles. Our method achieves strong results on the FPR95 metric, critical for safety-sensitive applications across multiple benchmarks, while also achieving competitive AUROC. Overall, our findings demonstrate that the sparse, disentangled features revealed by SAEs can serve as a powerful, interpretable tool for robust OOD detection in vision models.
Out-of-distribution (OOD) detection is essential for deploying machine learning models in open-world and safety-critical scenarios, where test inputs may deviate from the training distribution and overconfident predictions on unknown samples can lead to unreliable decisions. Outlier Exposure (OE) has emerged as a promising OOD detection paradigm by introducing auxiliary outliers during training to enlarge the margin between in-distribution (ID) and OOD samples. Existing OE-based methods typically enlarge this margin by employing uniform labels to maximize the entropy of OOD samples over ID categories. However, we theoretically show that uniform labels inevitably disregard the relations between OOD samples and ID categories, termed the over-softening effect, leading to a suboptimal margin bound. Our theoretical analysis further reveals that explicitly exploiting such relations can instead yield improved OOD detection performance. Motivated by this insight, we propose \underline{A}daptive Confidence \underline{OE} (AOE), a simple yet effective method that leverages temperature scaling to recalibrate outlier labels. Specifically, AOE generates adaptive soft targets from temperature-scaled model predictions for OOD samples, where the learnable temperature smooths the prediction distribution without fully erasing class-wise relational information. By supervising OOD samples with these adaptive soft targets, AOE preserves the semantic proximity between OOD samples and ID categories while encouraging the softened targets to approach a high-entropy distribution, thereby suppressing overconfident OOD predictions and enlarging the separation margin. Extensive experiments across diverse benchmarks demonstrate the effectiveness of AOE.