Organizations: Wysa Inc., Boston, MA, United States
Abstract
Digital mental health interventions (DMHIs) offer scalable support, but ensuring they accurately detect users' intent during volatile situations can be challenging. Pure parametric Large Language models (LLMs) do not contain specific safety critical architecture, and can miss critical cues, or hallucinate, undermining reliability. Retrieval Augmented Generation (RAG), which supplements an LLM with retrieved context, could enhance intent detection during volatile situations. Commercially available DMHIs typically combine multiple independent safety layers like rule-based filters, symbolic escalation protocols, and neural classification. The incremental contribution of any single layer, however, remains unquantified. This paper evaluates six LLM models within a DMHI called Wysa, via a controlled comparison of RAG-enabled versus RAG-disabled modes. Anonymized real and synthetic user-chatbot exchanges were annotated by a qualified clinical team against multi-class intent categories (e.g. self-harm, abuse, panic). The study computed classification accuracy, recall, precision and F1 scores against ground truth labels and tested differences for statistical significance. Performance was also examined by risk category and inter-model agreement. While RAG caused a rise in false alarms, the trade-off is consistent with safety-critical design principles that prioritize sensitivity, where flagged cases are routed to additional review rather than acted on directly. Overall, these findings support RAG as a promising approach to improve the accuracy, consistency and safety of LLM-driven DMHIs. Keywords: Digital Mental Health Intervention, Large Language Model, Retrieval Augmented Generation, Accuracy, Recall, Precision
Large language models (LLMs) are increasingly used for emotional support despite lacking mechanisms to safely govern evolving mental health risk. Existing safety approaches primarily detect risk but rarely shape how models respond as conversational risk unfolds. We developed a model-agnostic safety governance architecture that combines contextual risk detection, reasoning-based verification, and protocol-guided response generation for multi-turn mental health interactions. Synthetic conversations grounded in real-world mental health narratives were used to evaluate the architecture's performance, tested with GPT-5-chat and Qwen3.5-27B, achieving high risk detection performance (specificity: 0.85 (95%CI: 0.78;0.91), sensitivity: 0.92 (95%CI: 0.88;0.95)) and increasing clinician-preferred escalation responses by 25.6--59.2pp while preserving rapport and connection. Performance remained stable across conversation length and generalized across both proprietary and open-source models. These findings demonstrate that clinically-grounded safety governance can extend beyond risk detection to improve how LLMs manage evolving mental health risk, providing a scalable framework for safer deployment across models.
Anabela C. Areias, Catarina Botelho, António Farinhas +7
Retrieval-augmented generation (RAG) can improve the specificity and grounding of large language model responses, but its effect is not uniformly beneficial in single-turn mental-health question answering, where user queries often combine emotional distress, treatment concerns, and safety-sensitive needs. We study when retrieval helps or hurts mental-health QA, and whether a lightweight selective retrieval policy can better control this trade-off. We operationalize retrieval need using three draft-conditioned utility dimensions: psychoeducational need, coping need, and response specificity, together with a rule-based safety trigger. Following psychotherapy-grounded RAG systems such as coTherapist, we construct a compact and controllable guideline corpus comprising coping-strategy, psychoeducational, and safety resources. We fine-tune an instruction-tuned generator on MentalChat16K using QLoRA and compare Closed-book, Always Retrieval, and Selective Retrieval settings on CounselBench-Eval and CounselBench-Adv. Experiments show that retrieval is not uniformly beneficial in this domain. Always Retrieval improves specificity but lowers overall quality and introduces additional safety-sensitive failures. Selective Retrieval preserves closed-book behavior for low-need cases while avoiding the additional degradation caused by unconditional retrieval, supporting the view that retrieval activation is a safety-sensitive control decision.
General-purpose large language models (LLMs) are increasingly used for mental health-related conversations, yet safety guardrails remain inadequate and inconsistent across clinical conditions. This study evaluates eight proprietary LLMs across 16 DSM-5 conditions using four adversarial attack variants, introducing an eight-dimension harm taxonomy and a multi-dimensional evaluation framework. Results show that safeguards hold reliably only for suicide and self-harm, while conditions such as eating disorders, substance use disorder, and major depressive disorder exhibit failure rates of up to 100%. We argue that ethical design and deployment of these LLMs demand clearly defined harm categories across clinical conditions and implementation of safeguards accordingly. Until such safeguards are in place, these models pose significant risks to vulnerable populations, making their growing integration into publicly available settings (e.g., schools, search engines, and consumer chatbots) are particularly concerning.
Annika Marie Schoene, Cansu Canca, Gautham Vijay Kumar +1