MoPET: Parameter-Efficient Mixture-of-Experts for Unified Medical Image Classification
Authors: Sebastian Doerrich, Daniel Würtinger, Francesco Di Salvo, Shyam Nandan Rai, Christian Ledig
Organizations: xAILab Bamberg, University of Bamberg, Bamberg, Germany
Abstract
Adapting deep learning models to profound clinical heterogeneity typically relies on parameter-efficient fine-tuning (PEFT) to avoid the severe overfitting associated with full end-to-end network updates. Although PEFT successfully navigates limited data scenarios, it inherently forces the training of a separate, isolated adapter for every specific diagnostic task. Consolidating these isolated adapters into a single generalist network risks negative transfer, as optimization gradients from conflicting visual domains interfere. To address this, we propose MoPET, a mixture-of-experts (MoE) method that uses a learned sparse router to direct each input through a small subset of low-rank PEFT experts injected into a frozen foundation model, sharing capacity across datasets while limiting cross-domain gradient conflict. Through selected evaluations on the MedMNIST benchmark, we first establish that PEFT outperforms full network updates, improving average accuracy from 86.50% to 88.97%. We then show that a single MoPET model consolidates four heterogeneous datasets into one network, improving average accuracy over the best isolated PEFT adapters (93.46% versus 92.83%). Finally, we show that co-training with auxiliary datasets improves accuracy on data-constrained clinical targets, raising average target accuracy over the strongest isolated adapter from 81.58% to 83.58%. Our source code is publicly available at https://github.com/sdoerrich97/mopet.
Medical vision-language models (MVLMs) promise broad zero-shot generalization, yet their reliability collapses when confronted with unseen modalities and domains, precisely where clinical robustness matters most. To address this gap, we revisit test-time modality generalization from the perspective of Mixture-of-Experts (MoE) and ask: can experts route-and-adapt without any optimization during inference? We identify a fundamental specialization-generalization dilemma at test time, where blindly aggregating modality experts dilutes modality-specific knowledge, while selecting one highly confident expert risks mismatch under shift. To address this, we propose MoBE: a fully optimization-free framework that performs dynamic expert selection and adaptation at test time. MoBE combines entropy-guided dynamic routing in MoE settings with expert-wise Bayesian adaptation, enabling experts to update their confidence and adapt online without gradient updates. Without parametric updates, MoBE augments a static MVLM with test-time routing and online statistics, achieving average accuracy gains of +4.72, +7.17, and +4.3 over state-of-the-art TTA methods across seen, unseen, and heterogeneous medical benchmarks, highlighting the effectiveness of training-free expert adaptation for robust modality generalization.
Mixture-of-Experts (MoE) models scale efficiently but remain costly to adapt due to redundant experts and uniform parameter allocation. Existing parameter-efficient fine-tuning (PEFT) methods such as LoRA ignore MoE routing dynamics, leading to suboptimal resource use. We propose EPnG, an adaptive prune-and-grow framework that reallocates LoRA capacity based on expert importance derived from router gate probabilities. EPnG prunes under-utilized experts and expands high-importance experts via rank growth with orthogonal initialization, while maintaining a fixed parameter budget. Across OLMoE and Qwen1.5-MoE, EPnG consistently outperforms LoRA under the same budget and achieves performance comparable to full fine-tuning while updating only 0.55%-0.72% of parameters (up to 140x-180x fewer). These results demonstrate that aligning PEFT with MoE routing yields a more effective and scalable fine-tuning strategy.
Mixture-of-Experts (MoE) architectures have been widely adopted in large language models, yet parameter-efficient fine-tuning (PEFT) for MoE models remains underexplored. Existing PEFT methods for MoE either ignore router priors with uniform adapters, reducing efficiency and risking forgetting, or rely on static expert selection, limiting per-token capacity and cross-expert feature learning. In this paper, we make the first attempt to fine-tune MoE models with MoE-style low-rank adaptation: our method, entitled MoE2-LoRA, deeply couples the pretrained expert specialization with task-specific adaptivity via a dual-channel Routing-Conditioned Projection (RCP) module, which reuses base router activations to inform LoRA routing. We further introduce a single global LoRA expert pool shared across all layers, enabling model-wide adaptation with emergent layer-wise affinities and balanced expert utilization. MoE2-LoRA simultaneously benefits from the advantages of prior reuse, dynamic adapter routing, and model-wide knowledge sharing. Evaluated on multiple MoE backbones with varying scales and expert granularities, MoE2-LoRA consistently achieves state-of-the-art downstream accuracy while retaining stronger general capabilities.