Auditing Patient Privacy in Medical Generative Models: Scalable Memorization Detection with DeepSSIM++

The tendency of large generative models to memorize training data makes sample verification critical for privacy auditing and copyright enforcement. Current membership (MIA) and dataset inference (DI) attacks often rely on one-shot generations, which yield weak signals and limited sensitivity across modalities. Inspired by Model Autophagy Disorder (MAD), we introduce MADreMIA, a model-agnostic framework that enhances white-, gray-, and black-box MIA and DI. Rather than relying on shadow model training -- often infeasible for large generative models -- our framework facilitates scalable inference by leveraging inherent signals through iterative trajectories. This process utilizes chained generations across diverse modalities, where each output serves as the subsequent input, to improve membership evidence at low FPR. We demonstrate that memorized training samples exhibit significantly higher coherence and slower degradation during iterative regeneration than non-member generations. Our results show that MADreMIA provides richer signals across diverse model families and modalities; we present comprehensive evaluations for IARs, diffusion, and language models, alongside preliminary results demonstrating its potential for audio models.

In medical imaging, generative models are increasingly deployed to synthesize realistic data and augment limited datasets. Unfortunately, while beneficial for privacy-preserving data sharing, these synthesized images can be repurposed for malicious intents, threatening public health through the creation of Medical Deepfakes. To address this threat, we introduce the K-Space Signature (KSS), a novel forensic framework that isolates hardware and generative traces within the spectral domain. By shifting analysis to the frequency domain, the KSS suppresses macroscopic anatomical variance by subtracting an empirical global anatomical prior computed in the Logarithmic Power Spectral Density (Log-PSD) space. To effectively process these globally distributed spectral artifacts without the local spatial bias inherent to Convolutional Neural Networks, we pair the KSS representation with a novel 3D MLP-Mixer architecture equipped with an ArcFace metric-learning head. Extensive experiments on multi-center 3D MRI datasets demonstrate that this combined approach achieves exceptional detection performance, exceeding 0.99 Accuracy and ROC-AUC on multi-generator synthetic datasets. Furthermore, the framework exhibits robust zero-shot generalization, maintaining strong discriminative power (up to 0.93 Accuracy) on independent datasets acquired from entirely unseen scanners. To ensure full reproducibility, the complete source code and pre-trained models will be made publicly available upon acceptance.

While diffusion models excel at generating high-quality images, their tendency to memorize training data poses significant privacy and copyright risks. In this work, we for the first time identify that memorization induces internal numerical instability, often manifesting as visually ``broken'' artifacts. Inspired by stability analysis in numerical methods, we introduce empirical stability regions based on latent update norms to quantitatively characterize stable behavior during generation. Leveraging this, we propose a principled, on-the-fly framework for step-wise detection and adaptive mitigation. Our approach suppresses memorization without altering prompts or guidance, thereby preserving semantic fidelity and image quality. Extensive experiments on Stable Diffusion 1.4 demonstrate that our method achieves an AUC $>0.999$ detection performance and a $0.0\%$ memorization rate after mitigation with negligible overhead ($\approx0.01$s per image).