OmniMed-FL: A Robust Multimodal Federated Learning Framework for Clinical Diagnosis

Ayush Debnath; Ruelia Saha; Sudip Misra

cs.LGSep 9, 2026

OmniMed-FL: A Robust Multimodal Federated Learning Framework for Clinical Diagnosis

Authors: Ayush Debnath, Ruelia Saha, Sudip Misra

Abstract

Simultaneous assessment of medical imaging and patient records is often required in clinical diagnosis. However, standard machine learning algorithms cannot analyze these data types together. Meanwhile, compliance with HIPAA and GDPR can constrain centralized aggregation of sensitive patient data. This leaves a crucial void of secure fusion of visual and textual context across distant networks. Thus, we present OmniMed-FL, a controlled systems study of multimodal federated learning for five-class clinical condition classification (Normal, Pneumonia, COVID-19, Pleural Effusion, Cardiomegaly). Our proxy corpus pairs 3,000 public chest radiographs with 3,000 class-conditioned synthetic notes, matched by class, not by patient. The framework benchmarks eight fusion strategies, three initializations, four missing-text imputation rules, and matched federated baselines under non-IID Dirichlet partitioning across 3 to 20 hospital clients. As all notes are synthetic and pairing is not patient-level, these are descriptive proxy comparisons, not estimates of diagnostic performance or deployment readiness. Within those limits with clients ( $K=5$ ) and severe skew ( $α=0.1$ ), local-only training achieves a macro-F1 score of 0.297, FedAvg achieves $0.662\pm0.074$ , FedProx $0.737\pm0.085$ , a matched FedMME-style one-shot ensemble $0.647\pm0.080$ , and our SCAFFOLD-AdamW adaptation $0.070\pm0.015$ , the 0.075 FedProx-FedAvg gap falling inside the wider of the two two-seed standard deviations. Over a $4\times3$ grid, label skew costs up to 0.27 F1 whereas a near-sevenfold client increase costs at most 0.10, while bidirectional volume grows linearly to 183.5 GiB at $K=20$ . Multimodal fusion leads on both corpora, scoring 0.956 against 0.934 for text and 0.664 for images on the synthetic corpus and 0.906 against 0.880 and 0.737 on the radiograph corpus, for $2.3\times$ the model state of text alone.

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