Overview of BioASQ 2026: The fourteenth BioASQ Challenge on Large-Scale Biomedical Semantic Indexing and Question Answering

Biomedical question answering requires not only accurate extraction of information from scientific literature but also reliable integration of evidence across multiple documents. This study presents a question-type-specific large language model (LLM) framework for BioASQ 14b Task B, designed to improve answer robustness and evidence grounding in biomedical question answering. Rather than applying a single prompting strategy to all questions, the framework selects different inference procedures for yes/no, factoid, and list questions according to their distinct reasoning and evaluation requirements. For yes/no questions, snippet shuffling and self-reflection are used to reduce sensitivity to evidence ordering and improve decision stability. For factoid questions, full-snippet input is combined with chain-of-thought-based in-context learning to support accurate biomedical entity identification. For list questions, a multi-agent architecture is employed, in which evidence extraction, candidate generation, answer verification, and final aggregation are handled collaboratively. Preliminary experiments on BioASQ 13b were used to identify effective inference strategies for each question type, and the resulting framework was subsequently evaluated in the official BioASQ 14b Task B challenge. In the official evaluation, our framework showed competitive performance across multiple batches and achieved first place in the factoid subtask of Batch 4. These results demonstrate the effectiveness of combining question-type-specific inference, ensemble prediction, and agent-based verification for reliable biomedical question answering.

We describe our BioASQ Task 14B 2026 system. The work centers on two design decisions: how aggressively to re-retrieve when first-stage retrieval is weak, and how to combine multiple language-model answers. Retrieval unions two parallel pipelines - a hybrid first stage (dense BGE + BM25 + RRF, reaching R@200 = 99.3% on the BioASQ-13b historical archive) and an agent-driven pipeline that decomposes the question over PubMed, Europe PMC, and iCite - with a BGE cross-encoder quality gate flagging weakly-supported questions for selective re-retrieval. On Task 12B 2024 validation, a cost-pragmatic re-retrieval policy beats a skill-strict baseline significantly on list F1 and list precision, at 12% lower re-retrieval cost. Holding prompt and model fixed across val and test 13B (different question sets), list F1 rises by +0.132 absolute on the BioASQ-released gold-input pool, consistent with substantial retrieval-side headroom. For Phase B answering we decompose multi-model ensemble lift into a selection component bounded by the per-question oracle and a fusion component that aggregators can exceed. The decomposition predicts before any experiment that LLM-as-judge wins on selection-dominated metrics (yes/no, multi-reference ROUGE) but is structurally insufficient on the recall component of fusion-friendly metrics (factoid rank-1, list recall). On Task 13B 2025 our synonym-union resolver wins list recall on every head, while GPT-5.5 solo retains the list-F1 lead because the resolver's wider item set costs precision. On the Task 14B 2026 preliminary leaderboard our team places first on the combined-exact aggregate on three of the eight (phase x batch) leaderboards, wins four individual question-type cells, and takes #1 on Phase B b3 ideal.

This work presents DS@GT ARC BioASQ team's work for a biomedical question answering pipeline, integrating multi-source query expansion, neural reranking, retrieval refinement, and OpenBioLLM-assisted answer generation. The system combines PubMed retrieval with fine-tuned MiniLM-based semantic reranking, Reciprocal Rank Fusion (RRF), and feature-based relevance scoring to improve document ranking quality. To address challenging queries with weak retrieval performance, we introduce a conditional weak-question recovery strategy that applies semantic expansion, relationship-aware augmentation, and selective result merging. A post-retrieval pruning stage further removes redundant or low-relevance snippets while preserving evidence coverage for downstream answer generation. Experimental results on BioASQ evaluation batches demonstrate that the proposed recovery and cleanup strategies substantially improve retrieval robustness and MAP@10 performance on difficult question sets. The final system also incorporates output validation and post-processing steps to ensure formatting consistency and submission reliability across BioASQ phases.