Image Restoration

Recent momentum

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11 papers in the last 28 days · 0.2% of indexed attention

Twelve weeks of publication activity for this topic as it is defined today.

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Period ending 2026-09-21

1 new paper

A weekly snapshot of new work published in Image Restoration.

Period ending 2026-09-14

4 new papers

A weekly snapshot of new work published in Image Restoration.

Period ending 2026-09-07

3 new papers

A weekly snapshot of new work published in Image Restoration.

140 papers

Latest in Image Restoration

Apr 20, 2026cs.CV

CFSR: Geometry-Conditioned Shadow Removal via Physical Disentanglement

Traditional shadow removal networks often treat image restoration as an unconstrained mapping, lacking the physical interpretability required to balance localized texture recovery with global illumination consistency. To address this, we propose CFSR, a multi-modal prior-driven framework that reframes shadow removal as a physics-constrained restoration process. By seamlessly integrating 3D geometric cues with large-scale foundation model semantics, CFSR effectively bridges the 2D-3D domain gap. Specifically, we first map observations into a custom HVI color space to suppress shadow-induced noise and robustly fuse RGB data with estimated depth priors. At its core, our Geometric & Semantic Dual Explicit Guided Attention mechanism utilizes DINO features and 3D surface normals to directly modulate the attention affinity matrix, structurally enforcing physical lighting constraints. To recover severely degraded regions, we inject holistic priors via a frozen CLIP encoder. Finally, our Frequency Collaborative Reconstruction Module (FCRM) achieves an optimal synthesis by decoupling the decoding process. Conditioned on geometric priors, FCRM seamlessly harmonizes the reconstruction of sharp high-frequency occlusion boundaries with the restoration of low-frequency global illumination. Extensive experiments demonstrate that CFSR achieves state-of-the-art performance across multiple challenging benchmarks.
Pan Wang, Yihao Hu, Xiujin Liu +1
Apr 19, 2026cs.CV

MESA: A Training-Free Multi-Exemplar Deep Framework for Restoring Ancient Inscription Textures

Ancient inscriptions frequently suffer missing or corrupted regions from fragmentation, erosion, or other damage, hindering reading, and analysis. We review prior image restoration methods and their applicability to inscription image recovery, then introduce MESA (Multi-Exemplar, Style-Aware) -an image-level restoration method that uses well-preserved exemplar inscriptions (from the same epigraphic monument, material, or similar letterforms) to guide reconstruction of damaged text. MESA encodes VGG19 convolutional features as Gram matrices to capture exemplar texture, style, and stroke structure; for each neural network layer it selects the exemplar minimizing Mean-Squared Displacement (MSD) to the damaged input. Layer-wise contribution weights are derived from Optical Character Recognition-estimated character widths in the exemplar set to bias filters toward scales matching letter geometry, and a training mask preserves intact regions so synthesis is restricted to damaged areas. We also summarize prior network architectures and exemplar and single-image synthesis, inpainting, and Generative Adversarial Network (GAN) approaches, highlighting limitations that MESA addresses. Comparative experiments demonstrate the advantages of MESA. Finally, we provide a practical roadmap for choosing restoration strategies given available exemplars and metadata.
Vasileios Toulatzis, Sofia Theodoridou, Ioannis Fudos
Apr 18, 2026cs.CV

StomaD2: An All-in-One System for Intelligent Stomatal Phenotype Analysis via Diffusion-Based Restoration Detection Network

Stomata play a crucial role in regulating plant physiological processes and reflecting environmental responses. However, accurate and high-throughput stomatal phenotyping remains challenging, as conventional approaches rely on destructive sampling and manual annotation, restricting large-scale and field deployment. To overcome these limitations, a noninvasive restoration-detection integrated framework, termed StomaD2, is developed to achieve accurate and fast stomatal phenotyping under complex imaging conditions. The framework incorporates a diffusion-based restoration module to recover degraded images and a specialized rotated object detection network tailored to the small, dense, and cluttered characteristics of stomata. The proposed network enhances feature representation through three key innovations: a column-wise structure for global feature interaction, context-aware resampling and reweighting mechanism to improve multi-scale consistency, and a feature reassembly module to boost discrimination against complex backgrounds. In extensive comparisons, StomaD2 demonstrated state-of-the-art performance. On public Maize and Wheat datasets, it achieved accuracies of 0.994 and 0.992, respectively, significantly outperforming existing benchmarks. When benchmarked against ten other advanced models, including Oriented Former and YOLOv12, StomaD2 achieved a top-tier F1-score/mAP of 0.989. The framework is integrated into a user-friendly, field-operable system that supports the fast extraction of eight stomatal phenotypes, such as density and conductance. Validated on more than 130 plant species, StomaD2's results highlight its strong generalizability and potential for large-scale phenotyping, plant physiology analysis, and precision agriculture applications.
Quanling Zhao, Meng'en Qin, Yanfeng Sun +2
Apr 18, 2026cs.CV

Frequency-Decomposed INR for NIR-Assisted Low-Light RGB Image Denoising

Addressing the issues of severe noise and high frequency structural degradation in visible images under low-light conditions, this paper proposes a Near Infrared (NIR) aided low light image restoration method based on Frequency Decoupled Implicit Neural Representation (FDINR). Based on the statistical prior of RGB-NIR cross-modal frequency correlations, specifically that low-frequency RGB signals are more reliable, whereas high frequency NIR signals exhibit higher correlation, we explicitly decompose images into distinct frequency components via multi-scale wavelet transforms and construct a dual-branch implicit neural representation framework. Within this framework, we design a cross modal differentiated frequency supervision mechanism, leveraging low light RGB to guide the reconstruction of low frequency luminance and color, and utilizing high-SNR NIR signals to constrain the generation of high frequency texture details, thereby achieving complementary advantages in the frequency domain. Furthermore, an uncertainty-based adaptive weighting loss function is introduced to automatically balance the contributions of different frequency tasks, solving the problems of color distortion and artifacts caused by rigid fusion in the spatial domain common in traditional methods. Experimental results demonstrate that FD-INR not only effectively restores image luminance consistency and structural details but also, benefitting from its implicit continuous representation, outperforms existing methods in arbitrary-resolution reconstruction tasks, significantly enhancing the reliability of low light perception.
Ligen Shi, Zengyu Pang, Chang Liu +2
Apr 17, 2026cs.CV

Diffusion Autoencoder for Unsupervised Artifact Restoration in Handheld Fundus Images

The advent of handheld fundus imaging devices has made ophthalmologic diagnosis and disease screening more accessible, efficient, and cost-effective. However, images captured from these setups often suffer from artifacts such as flash reflections, exposure variations, and motion-induced blur, which degrade image quality and hinder downstream analysis. While generative models have been effective in image restoration, most depend on paired supervision or predefined artifact structures, making them less adaptable to unstructured degradations commonly observed in handheld fundus images. To address this, we propose an unsupervised diffusion autoencoder that integrates a context encoder with the denoising process to learn semantically meaningful representations for artifact restoration. The model is trained only on high-quality table-top fundus images and infers to restore artifact-affected handheld acquisitions. We validate the restorations through quantitative and qualitative evaluations, and have shown that diagnostic accuracy increases to 81.17% on an unseen dataset and multiple artifact conditions
Mathumetha Palani, Kavya Puthumana, Ayantika Das +1
Apr 17, 2026cs.CV

From Zero to Detail: A Progressive Spectral Decoupling Paradigm for UHD Image Restoration with New Benchmark

Ultra-high-definition (UHD) image restoration poses unique challenges due to the high spatial resolution, diverse content, and fine-grained structures present in UHD images. To address these issues, we introduce a progressive spectral decomposition for the restoration process, decomposing it into three stages: zero-frequency \textbf{enhancement}, low-frequency \textbf{restoration}, and high-frequency \textbf{refinement}. Based on this formulation, we propose a novel framework, \textbf{ERR}, which integrates three cooperative sub-networks: the zero-frequency enhancer (ZFE), the low-frequency restorer (LFR), and the high-frequency refiner (HFR). The ZFE incorporates global priors to learn holistic mappings, the LFR reconstructs the main content by focusing on coarse-scale information, and the HFR adopts our proposed frequency-windowed Kolmogorov-Arnold Network (FW-KAN) to recover fine textures and intricate details for high-fidelity restoration. To further advance research in UHD image restoration, we also construct a large-scale, high-quality benchmark dataset, \textbf{LSUHDIR}, comprising 82{,}126 UHD images with diverse scenes and rich content. Our proposed methods demonstrate superior performance across a range of UHD image restoration tasks, and extensive ablation studies confirm the contribution and necessity of each module. Project page: https://github.com/NJU-PCALab/ERR.
Chen Zhao, Yunzhe Xu, Zhizhou Chen +5
Apr 16, 2026cs.CV

OmniLight: One Model to Rule All Lighting Conditions

Adverse lighting conditions, such as cast shadows and irregular illumination, pose significant challenges to computer vision systems by degrading visibility and color fidelity. Consequently, effective shadow removal and ALN are critical for restoring underlying image content, improving perceptual quality, and facilitating robust performance in downstream tasks. However, while achieving state-of-the-art results on specific benchmarks is a primary goal in image restoration challenges, real-world applications often demand robust models capable of handling diverse domains. To address this, we present a comprehensive study on lighting-related image restoration by exploring two contrasting strategies. We leverage a robust framework for ALN, DINOLight, as a specialized baseline to exploit the characteristics of each individual dataset, and extend it to OmniLight, a generalized alternative incorporating our proposed Wavelet Domain Mixture-of-Experts (WD-MoE) that is trained across all provided datasets. Through a comparative analysis of these two methods, we discuss the impact of data distribution on the performance of specialized and unified architectures in lighting-related image restoration. Notably, both approaches secured top-tier rankings across all three lighting-related tracks in the NTIRE 2026 Challenge, demonstrating their outstanding perceptual quality and generalization capabilities. Our codes are available at https://github.com/OBAKSA/Lighting-Restoration.
Youngjin Oh, Junyoung Park, Junhyeong Kwon +1
Mar 29, 2026cs.CV

TIR-Agent: Training an Explorative and Efficient Agent for Image Restoration

Vision-language agents that orchestrate specialized tools for image restoration (IR) have emerged as a promising method, yet most existing frameworks operate in a training-free manner. They rely on heuristic task scheduling and exhaustive tool traversal, resulting in sub-optimal restoration paths and prohibitive computational cost. We argue that the core bottleneck lies in the absence of a learned policy to make decision, as a vision-language model cannot efficiently handle degradation-aware task ordering and tool composition. To this end, we propose TIR-Agent, a trainable image restoration agent that performs a direct tool-calling policy through a two-stage training pipeline of supervised fine-tuning (SFT) followed by reinforcement learning (RL). Two key designs underpin effective RL training: (i) a random perturbation strategy applied to the SFT data, which broadens the policy's exploration over task schedules and tool compositions, and (ii) a multi-dimensional adaptive reward mechanism that dynamically re-weights heterogeneous image quality metrics to mitigate reward hacking. To support high-throughput, asynchronous GPU-based tool invocation during training, we further develop a globally shared model-call pool. Experiments on both in-domain and out-of-domain degradations show that TIR-Agent outperforms 12 baselines, including 6 all-in-one models, 3 training-free agents, and 3 proprietary models, and achieves over 2.5×\times inference speedup by eliminating redundant tool executions.
Guoli Jia, Yisheng Zhang, Haote Hu +11
Mar 20, 2026cs.CV

Improving Image-to-Image Translation via a Rectified Flow Reformulation

In this work, we propose Image-to-Image Rectified Flow Reformulation (I2I-RFR), a practical plug-in reformulation that recasts standard I2I regression networks as continuous-time transport models. While pixel-wise I2I regression is simple, stable, and easy to adapt across tasks, it often over-smooths ill-posed and multimodal targets, whereas generative alternatives often require additional components, task-specific tuning, and more complex training and inference pipelines. Our method augments the backbone input by channel-wise concatenation with a noise-corrupted version of the ground-truth target and optimizes a simple t-reweighted pixel loss. This objective admits a rectified-flow interpretation via an induced velocity field, enabling ODE-based progressive refinement at inference time while largely preserving the standard supervised training pipeline. In most cases, adopting I2I-RFR requires only expanding the input channels, and inference can be performed with a few explicit solver steps (e.g., 3 steps) without distillation. Extensive experiments across multiple image-to-image translation and video restoration tasks show that I2I-RFR generally improves performance across a wide range of tasks and backbones, with particularly clear gains in perceptual quality and detail preservation. Overall, I2I-RFR provides a lightweight way to incorporate continuous-time refinement into conventional I2I models without requiring a heavy generative pipeline.
Satoshi Iizuka, Shun Okamoto, Kazuhiro Fukui
Mar 19, 2026cs.CV

FUMO: Prior-Modulated Diffusion for Single Image Reflection Removal

Single image reflection removal (SIRR) is challenging in real scenes, where reflection strength varies spatially and reflection patterns are tightly entangled with transmission structures. This paper presents a diffusion model with prior modulation framework (FUMO) that introduces explicit priors for spatially adaptive conditioning and structurally faithful restoration. Two priors are extracted directly from the mixed image, an intensity prior that estimates spatial reflection severity and a high-frequency prior that captures detail-sensitive responses via multi-scale residual aggregation. We propose a coarse-to-fine training paradigm. In the first stage, these cues are combined to gate the conditional residual injections, focusing the conditioning on regions that are both reflection-dominant and structure-sensitive. In the second stage, a fine-grained refinement network corrects local misalignment and sharpens fine details in the image space. Experiments conducted on both standard benchmarks and challenging images in the wild demonstrate competitive quantitative results and consistently improved perceptual quality. The code is released at https://github.com/Lucious-Desmon/FUMO.
Telang Xu, Chaoyang Zhang, Guangtao Zhai +1
Dec 21, 2025cs.CV

Rectification Reimagined: A Unified Mamba Model for Image Correction and Rectangling with Prompts

Image correction and rectangling are valuable tasks in practical photography systems such as smartphones. Recent remarkable advancements in deep learning have undeniably brought about substantial performance improvements in these fields. Nevertheless, existing methods mainly rely on task-specific architectures. This significantly restricts their generalization ability and effective application across a wide range of different tasks. In this paper, we introduce the Unified Rectification Framework (UniRect), a comprehensive approach that addresses these practical tasks from a consistent distortion rectification perspective. Our approach incorporates various task-specific inverse problems into a general distortion model by simulating different types of lenses. To handle diverse distortions, UniRect adopts one task-agnostic rectification framework with a dual-component structure: a {Deformation Module}, which utilizes a novel Residual Progressive Thin-Plate Spline (RP-TPS) model to address complex geometric deformations, and a subsequent Restoration Module, which employs Residual Mamba Blocks (RMBs) to counteract the degradation caused by the deformation process and enhance the fidelity of the output image. Moreover, a Sparse Mixture-of-Experts (SMoEs) structure is designed to circumvent heavy task competition in multi-task learning due to varying distortions. Extensive experiments demonstrate that our models have achieved state-of-the-art performance compared with other up-to-date methods.
Linwei Qiu, Gongzhe Li, Xiaozhe Zhang +2
Dec 17, 2025physics.chem-ph

NMIRacle: Multi-modal Generative Molecular Elucidation from IR and NMR Spectra

Molecular structure elucidation from spectroscopic data is a long-standing challenge in Chemistry, traditionally requiring expert interpretation. We introduce NMIRacle, a two-stage generative framework that builds upon recent paradigms in AI-driven spectroscopy with minimal assumptions. In the first stage, NMIRacle learns to reconstruct molecular structures from count-aware fragment representations, capturing both fragment identities and their occurrences. In the second stage, a spectral encoder maps input spectra (IR, 1H-NMR, 13C-NMR) into a latent embedding used to condition the pre-trained generator, which is fine-tuned for direct spectra-to-molecule generation. This formulation bridges fragment-level chemical modeling with spectral evidence, yielding accurate molecular predictions. Empirical results demonstrate that NMIRacle outperforms existing baselines on molecular elucidation, while maintaining robust performance across increasing levels of molecular complexity.
Federico Ottomano, Yingzhen Li, Alex M. Ganose
Dec 11, 2025cs.CV

Generative Manifold Distillation: Aligning Restoration Trajectories with Natural Image Prior

Pre-trained image restoration models often fail on out-of-distribution (OOD) real-world degradations. Adapting to these domains is challenging as real-world data lacks paired ground truth, and unsupervised methods often require unstable architectural changes. We propose Generative Manifold Distillation (GMD), which reframes domain adaptation as geometric manifold alignment. GMD operates in a strictly unpaired setting, requiring only low-quality (LQ) target observations. By leveraging the flow-matching dynamics of a frozen text-to-image foundation model, GMD projects off-manifold restorations onto the natural image manifold to generate high-quality pseudo-targets. To ensure stability, a quality-gated manifold filter rejects off-manifold samples, while source-anchored trajectory regularization prevents error accumulation. Ultimately, GMD distills a powerful generative prior into an efficient restoration network. Experiments demonstrate that GMD seamlessly adapts to new distributions using only LQ inputs, drastically improving perceptual quality with zero architectural modifications or added inference latency.
Yuyang Hu, Mojtaba Sahraee-Ardakan, Arpit Bansal +4
Dec 11, 2025cs.CV

ClusIR: Towards Cluster-Guided All-in-One Image Restoration

All-in-One Image Restoration (AiOIR) aims to recover high-quality images from diverse degradations within a unified framework. However, existing methods often fail to explicitly model degradation types and struggle to adapt their restoration behavior to complex or mixed degradations. To address these issues, we propose ClusIR, a Cluster-Guided Image Restoration framework that explicitly models degradation semantics through learnable clustering and propagates cluster-aware cues across spatial and frequency domains for adaptive restoration. Specifically, ClusIR comprises two key components: a Probabilistic Cluster-Guided Routing Mechanism (PCGRM) and a Degradation-Aware Frequency Modulation Module (DAFMM). The proposed PCGRM disentangles degradation recognition from expert activation, enabling discriminative degradation perception and stable expert routing. Meanwhile, DAFMM leverages the cluster-guided priors to perform adaptive frequency decomposition and targeted modulation, collaboratively refining structural and textural representations for higher restoration fidelity. The cluster-guided synergy seamlessly bridges semantic cues with frequency-domain modulation, empowering ClusIR to attain remarkable restoration results across a wide range of degradations. Extensive experiments on diverse benchmarks validate that ClusIR reaches competitive performance under several scenarios.
Shengkai Hu, Jiaqi Ma, Xu Zhang +3
Oct 20, 2025cs.CV

CharDiff-LP: A Diffusion Model with Character-Level Guidance for License Plate Image Restoration

License plate image restoration is important not only as a preprocessing step for license plate recognition but also for enhancing evidential value, improving visual clarity, and enabling broader reuse of license plate images. We propose a novel diffusion-based framework with character-level guidance, CharDiff-LP, which effectively restores and recognizes severely degraded license plate images captured under realistic conditions. CharDiff-LP leverages fine-grained character-level priors extracted through external segmentation and Optical Character Recognition (OCR) modules tailored for low-quality license plate images. For precise and focused guidance, CharDiff-LP incorporates a novel Character-guided Attention through Region-wise Masking (CHARM) module, which ensures that each character's guidance is restricted to its own region, thereby avoiding interference with other regions. In experiments, CharDiff-LP significantly outperformed baseline restoration models in both restoration quality and recognition accuracy, achieving a 28.3% relative reduction in character error rate (CER) on the Roboflow-LP dataset compared with the best-performing baseline.
Kihyun Na, Gyuhwan Park, Injung Kim
May 29, 2025cs.LG

EquiReg: Equivariance Regularized Diffusion for Inverse Problems

Diffusion models represent the state-of-the-art for solving inverse problems such as image restoration tasks. Diffusion-based inverse solvers incorporate a likelihood term to guide prior sampling, generating data consistent with the posterior distribution. However, due to the intractability of the likelihood, most methods rely on isotropic Gaussian approximations, which can push estimates off the data manifold and produce inconsistent, poor reconstructions. We propose Equivariance Regularized (EquiReg) diffusion, a general plug-in framework that improves posterior sampling by penalizing trajectories that deviate from the data manifold. EquiReg formalizes manifold-preferential equivariant functions that exhibit low equivariance error for on-manifold samples and high error for off-manifold ones, thereby guiding sampling toward symmetry-preserving regions of the solution space. We highlight that such functions naturally emerge when training non-equivariant models with augmentation or on data with symmetries. EquiReg's largest gains are under reduced sampling and measurement consistency steps, where many methods suffer severe quality degradation. By regularizing trajectories toward the manifold, EquiReg implicitly accelerates convergence and enables high-quality reconstructions. EquiReg consistently improves performance in linear and nonlinear image restoration tasks and solving partial differential equations. Our code is available at https://github.com/Anima-Lab/EquiReg
Bahareh Tolooshams, Aditi Chandrashekar, Rayhan Zirvi +4
May 25, 2025cs.CV

Freqformer: Image-Demoiréing Transformer via Effective Frequency Decomposition

Image demoiréing remains a challenging task due to the complex interplay between texture corruption and color distortions caused by moiré patterns. Existing methods, especially those relying on direct image-to-image restoration, often fail to disentangle these intertwined artifacts effectively. While frequency-aware approaches offer a promising direction, their potential is hindered by the discrete transform (e.g., Haar wavelet or block-based DCT), which may suffer from spatial discontinuity, channel redundancy, and further cause error accumulation during their fixed inverse processes. In this paper, we present Freqformer, a Transformer-based framework specifically designed for image demoiréing through targeted frequency separation. Our method performs an effective frequency decomposition that splits moiré patterns into high-frequency spatially-localized textures and low-frequency scale-robust color distortions, which are then handled by a dual-branch architecture and an asymmetric training scheme tailored to their distinct characteristics. We further propose a learnable Frequency Composition Transform (FCT) module to adaptively fuse the frequency-specific outputs, enabling consistent and high-fidelity reconstruction. To better aggregate the spatial dependencies and the inter-channel complementary information, we introduce a Spatial-Aware Channel Attention (SA-CA) module that refines moiré-sensitive regions without incurring high computational cost. Extensive experiments on various demoiréing benchmarks demonstrate that Freqformer achieves state-of-the-art performance with a compact model size. The code will be made publicly available at https://github.com/xyLiu339/Freqformer.
Xiaoyang Liu, Bolin Qiu, Zheng Chen +5
May 22, 2025cs.CV

Fast and Accurate Image Restoration and Generation with Rank Enhanced Linear Attention

Transformer-based models have made remarkable progress in image restoration (IR) tasks. However, the quadratic complexity of self-attention in Transformer hinders its applicability to high-resolution images. Existing methods mitigate this issue with sparse or window-based attention, yet inherently limit global context modeling. Linear attention, a variant of softmax attention, demonstrates promise in global context modeling while maintaining linear complexity, offering a potential solution to the above challenge. Despite its efficiency benefits, vanilla linear attention suffers from a significant performance drop in IR, largely due to the low-rank nature of its attention map. To counter this, we propose Rank Enhanced Linear Attention (RELA), a simple yet effective method that enriches feature representations by integrating a lightweight depthwise convolution. Building upon RELA, we propose an efficient and effective Vision Transformer, named LAformer. LAformer eliminates hardware-inefficient operations such as softmax and window shifting, enabling efficient processing of high-resolution images. Extensive experiments across 7 IR tasks and 21 benchmarks demonstrate that LAformer outperforms SOTA methods and offers significant computational advantages. Furthermore, we extend LAformer to diffusion-based and flow-based visual generation, showcasing its strong potential as a competitive alternative to DiT and SiT. Code and models are available at https://github.com/shallowdream204/LAformer.
Yuang Ai
Apr 18, 2025cs.CV

Circular Quasiconformal Deturbulence: Geometry-Based Restoration from Multiple Turbulent Frames

Imaging through inhomogeneous media often results in severe distortions, posing significant challenges to downstream image-processing tasks. The lack of clean paired images makes supervised learning impractical, motivating unsupervised restoration approaches. In this work, we propose the Circular Quasi-Conformal Deturbulence (CQCD) framework, an unsupervised approach that reconstructs distortion-free images from multiple frames using a circular architecture. The framework minimizes reconstruction errors by jointly estimating forward and backward transformations between distorted observations and the restored image. A key advancement of CQCD is the integration of computational quasi-conformal geometry, which encourages bijective non-rigid deformations and improves the well-posedness of both forward and inverse mappings for cycle consistency. The deformation field is further regularized to preserve structural coherence and reduce non-physical artifacts such as folding or tearing. Additionally, tight-frame blocks are employed to effectively encode distortion-sensitive features, enhancing the precision of the restoration process. To assess the effectiveness of the proposed framework, extensive evaluations are conducted on synthetic and real-world image datasets. Experimental findings indicate that CQCD not only surpasses existing state-of-the-art deturbulence techniques in restoration quality but also achieves highly accurate deformation field estimation.
Chu Chen, Han Zhang, Lok Ming Lui
Mar 3, 2025eess.IV

Hyperspectral Image Restoration and Super-resolution with Physics-Aware Deep Learning for Biomedical Applications

Hyperspectral imaging is a powerful bioimaging tool which can uncover novel insights, thanks to its sensitivity to the intrinsic properties of materials. However, this enhanced contrast comes at the cost of system complexity, constrained by an inherent trade-off between spatial, spectral, and temporal resolution. To overcome this limitation, we present a self-supervised deep learning-based approach that restores and enhances pixel resolution post-acquisition without requiring external training data beyond the images to be restored. Fine-tuned using metrics aligned with the imaging model, our physics-aware method achieves a 16×\times pixel super-resolution enhancement and a 12×\times imaging speedup without the need of additional training data for transfer learning. Applied to both synthetic and experimental data from five different sample types, including healthy and diseased tissues, we demonstrate that the model preserves biological integrity, as we did not detect systematic loss of biological features or biologically consequential hallucinations in tested datasets. We also concretely demonstrate the model's ability to reveal disease-associated metabolic changes that would otherwise remain undetectable. Furthermore, we provide physical insights into the model's inner workings, paving the way for future refinements that could potentially reveal novel high resolution features in an explainable manner. All methods are available as open-source software on GitHub.
Yuchen Xiang, Zhaolu Liu, Monica Emili Garcia-Segura +12