Multimodal Pretraining

In this study, we propose an enhancement to the similarity computation mechanism in multimodal contrastive pretraining frameworks such as CLIP. Prior theoretical research has demonstrated that the optimal similarity metrics between paired modalities should correspond to the pointwise mutual information (PMI) between the two modalities. However, the current implementations of CLIP and its variants fail to fully utilize the underlying linear structure of PMI. We therefore propose KME-CLIP, which leverages this structure through the inner product in a reproducing kernel Hilbert space (RKHS). We theoretically prove that, under our assumptions, the KME-CLIP similarity can bring the contrastive loss arbitrarily close to its optimal value, which is attained by PMI, as the size of the point set grows, and we empirically evaluate KME-CLIP against CLIP and its kernel-based variants across several retrieval and classification tasks.

Multimodal Large Language Models (MLLMs) have demonstrated impressive capabilities in understanding common visual elements, largely due to their large-scale datasets and advanced training strategies. However, their effectiveness in medical applications remains limited due to the inherent discrepancies between data and tasks in medical scenarios and those in the general domain. Concretely, existing medical MLLMs face the following critical limitations: (1) limited coverage of medical knowledge beyond imaging, (2) heightened susceptibility to hallucinations due to suboptimal data curation processes, (3) lack of reasoning capabilities tailored for complex medical scenarios. To address these challenges, we first propose a comprehensive data curation procedure that (1) efficiently acquires rich medical knowledge data not only from medical imaging but also from extensive medical texts and general-domain data; and (2) synthesizes accurate medical captions, visual question answering (VQA), and reasoning samples. As a result, we build a multimodal dataset enriched with extensive medical knowledge. Building on the curated data, we introduce our medical-specialized MLLM: Lingshu. Lingshu undergoes multi-stage training to embed medical expertise and enhance its task-solving capabilities progressively. Besides, we preliminarily explore the potential of applying reinforcement learning with verifiable rewards paradigm to enhance Lingshu's medical reasoning ability. Additionally, we develop MedEvalKit, a unified evaluation framework that consolidates leading multimodal and textual medical benchmarks for standardized, fair, and efficient model assessment. We evaluate the performance of Lingshu on three fundamental medical tasks, multimodal QA, text-based QA, and medical report generation. The results show that Lingshu consistently outperforms the existing open-source multimodal models on most tasks ...