Seven Security Challenges in Cross-domain Multi-agent LLM Systems

Large language model (LLM) agents are rapidly moving from conversational interfaces to software components that plan, invoke tools, maintain memory, and act on external environments. This transition changes the nature of security risk. In agentic settings, failures are no longer limited to unsafe text generation. Untrusted content may redirect control flow, misuse tool privileges, corrupt persistent state, leak sensitive information, or trigger harmful external actions. At the same time, research on LLM agent security is expanding quickly but remains fragmented across attack families, defense layers, application domains, and evaluation settings. This paper synthesizes 247 papers through a lifecycle-based, systems-oriented framework that models agent security around the interaction of information flow, delegated authority, and persistent state. We organize the literature around four questions: how LLM agent security should be modeled, which threat surfaces and attack families dominate, what defenses have been proposed and with what tradeoffs, and how security claims are evaluated. We find that prompt injection and tool-mediated control-flow hijacking still dominate the field, while persistent state corruption and multi-agent propagation are becoming central emerging concerns. We further find that current defenses provide useful building blocks but remain weakly compositional, and that existing benchmarks still underrepresent long-horizon, stateful, and deployment-sensitive risks. We argue that secure LLM agents require explicit trust boundaries, principled privilege control, provenance-aware state management, and evaluation practices aligned with realistic operational settings.

Safe agents can fail together. Multi-agent LLM systems (MAS) move information, state, decisions, and authority across principal boundaries, creating failures that local checks may miss. Without an execution-level view, a multi-agent setting can easily be mistaken for evidence of a genuinely multi-agent security effect. We thus systematize MAS security through an execution-centered analysis of 197 works, covering six interaction interfaces, four adversary positions, seven system-level risks, and eight recurring attack paths. We introduce an A-I-R framework that organizes attacks by adversary position, interaction interface, and resulting system-level risk, unifying otherwise fragmented attack mechanisms across MAS. We organize defenses through a five-part contract covering path target, observation, intervention, trust boundary, and recovery, and identify path closure and recovery as key challenges. We audit 44 evaluation and benchmark works and identify open challenges in isolating interaction effects, designing comparable and diagnostic metrics, supporting reuse across MAS designs, and evaluating open-system operation. Together, these findings motivate an interaction-aware view of MAS security: trace attacks end to end, test whether defenses close those paths, and evaluate system-level effects with appropriate counterfactuals.

Large language model (LLM) agents are rapidly being integrated into real-world systems. Their autonomy and tool-use capabilities generate substantial value while simultaneously expanding the security attack surface. This survey provides a comprehensive overview of the opportunities and challenges of LLM agents in security, focusing on two core areas: (1) threats to LLM agents themselves and corresponding mitigation strategies (LLM agents self-security), and (2) the role of LLM agents in empowering the cybersecurity lifecycle across offense and defense (LLM agents empowered cybersecurity). We first examine the internal and external attack surfaces of agents, propose a taxonomy organized by threat sources, and analyze associated mitigations and evaluation frameworks. We then investigate how agent capabilities are applied in cybersecurity practice and present, to our knowledge, the first agent-empowerment framework aligned with the full cyber offense-defense lifecycle. By systematically surveying these two areas, we are the first to highlight a positive feedback synergy between LLM agents self-security and empowered cybersecurity, offering new insights for the advancement of both. We further identify current limitations and outline promising directions for future research. The insights provided aim to catalyze the coordinated development of LLM agents self-security and agent empowered cybersecurity, paving the way for more capable and robust agent applications.