DocHop-QA: Towards Multi-Hop Reasoning over Multimodal Document Collections

Evaluating large language models (LLMs) in the biomedical domain requires benchmarks that can distinguish reasoning from pattern matching and remain discriminative as model capabilities improve. Existing biomedical question answering (QA) benchmarks are limited in this respect. Multiple-choice formats can allow models to succeed through answer elimination rather than inference, while widely circulated exam-style datasets are increasingly vulnerable to performance saturation and training data contamination. Multi-hop reasoning, defined as the ability to integrate information across multiple sources to derive an answer, is central to clinically meaningful tasks such as diagnostic support, literature-based discovery, and hypothesis generation, yet remains underrepresented in current biomedical QA benchmarks. MedHopQA is a disease-centered multi-hop reasoning benchmark consisting of 1,000 expert-curated question-answer pairs introduced as a shared task at BioCreative IX. Each question requires synthesis of information across two distinct Wikipedia articles, and answers are provided in an open-ended free-text format. Gold annotations are augmented with ontology-grounded synonym sets from MONDO, NCBI Gene, and NCBI Taxonomy to support both lexical and concept-level evaluation. MedHopQA was constructed through a structured process combining human annotation, triage, iterative verification, and LLM-as-a-judge validation. To reduce leaderboard gaming and contamination risk, the 1,000 scored questions are embedded within a publicly downloadable set of 10,000 questions, with answers withheld, on a CodaBench leaderboard. MedHopQA provides both a benchmark and a reusable framework for constructing future biomedical QA datasets that prioritize compositional reasoning, saturation resistance, and contamination resistance as core design constraints.

Scientific reasoning is a key aspect of human intelligence, requiring the integration of multimodal inputs, domain expertise, and multi-step inference across various subjects. Existing benchmarks for multimodal large language models (MLLMs) often fail to capture the complexity and traceability of reasoning processes necessary for rigorous evaluation. To fill this gap, we introduce SciVQR, a multimodal benchmark covering 54 subfields in mathematics, physics, chemistry, geography, astronomy, and biology. SciVQR includes domain-specific visuals, such as equations, charts, and diagrams, and challenges models to combine visual comprehension with reasoning. The tasks range from basic factual recall to complex, multi-step inferences, with 46% including expert-authored solutions. SciVQR not only evaluates final answers but also examines the reasoning process, providing insights into how models reach their conclusions. Our evaluation of leading MLLMs, including both proprietary and open-source models, reveals significant limitations in handling complex multimodal reasoning tasks, underscoring the need for improved multi-step reasoning and better integration of interdisciplinary knowledge in advancing MLLMs toward true scientific intelligence. The dataset and evaluation code are publicly available at https://github.com/CASIA-IVA-Lab/SciVQR.

Multimodal Large Language Models (MLLMs) have achieved strong performance on structured visual understanding tasks such as chart and document question answering. However, existing benchmarks typically evaluate these domains in isolation, leaving underexplored a key capability: whether models can use textual context to determine how chart evidence should be selected, interpreted, and aggregated. We introduce DocHop, a benchmark for integrated chart--context reasoning in document-style images. In DocHop, the document narrative specifies multi-step compositional constraints, while charts provide the corresponding data values. Questions are grounded on a semantic reference label defined in the narrative, requiring models to resolve target entities from context before aggregating evidence across multiple charts. To enable systematic evaluation, we construct DocHop via a stochastic logic-first generation pipeline with controllable reasoning depth and visual density, covering 2,074 examples across six task categories. Experiments on a wide range of proprietary and open-source MLLMs show a substantial gap to human performance: annotators achieve over 90% accuracy, while the best model reaches only 62.83%. Reasoning-enhanced models consistently show improved results, but performance degrades as reasoning complexity increases. Overall, DocHop provides a controlled testbed for challenging multi-hop document reasoning.