A Machine Learning-Driven Solution for Denoising Inertial Confinement Fusion Images

This paper documents the implementation and evaluation of a self-supervised denoising framework on Inertial Confinement Fusion (ICF) images corrupted by Multiplicative Uniform noise: the \emph{Log-Domain Noisier2Inverse} framework. This framework is developed and analysed in this work; the key theoretical result -- that minimising the log-domain self-supervised loss is equivalent to supervised learning in the transformed domain -- is presented with full proof. We document significant implementation challenges arising from the unique characteristics of ICF imagery, describe the fixes applied at each stage, and report final quantitative results. The log-domain approach with per-image JSON Uniform noise loading (VariantB) achieves the best result: a mean PSNR of $21.41\db$ and SSIM of $0.8358$, a $+19.46\db$ improvement over the noisy input baseline of $1.95\db$, substantially outperforming BM3D log-domain ($4.47\db$, SSIM $0.5181$) and Noise2Self ($4.75\db$, SSIM $0.0177$). VariantA, using fixed Gaussian noise loading, achieves $21.39\db$ PSNR and SSIM $0.8436$. Of the three evaluated methods, Log-Domain Noisier2Inverse and Noise2Self are entirely self-supervised during training, requiring no clean ground truth data; BM3D is a classical filter-based method requiring no training at all. The clean reference images are used solely for quantitative evaluation of all three methods.

Propagation-based X-ray phase-contrast imaging (PBI) enables high-contrast visualization of lung structures and holds strong medical potential. However, safe translation to the clinic will require a substantial radiation dose reduction, which inevitably increases image noise. Supervised convolutional-neural-network-based denoising can restore image quality but depends on paired low- and high-dose datasets, which are rarely available in practice. Self-supervised methods avoid this limitation, yet most are not well adapted to the inverse problem of PBI computed tomography (CT). We introduce Neighbor2Inverse, a self-supervised denoising framework designed for low-dose PBI-CT that generalizes to clinical CT. Building on the Neighbor2Neighbor principle, each noisy projection is subsampled into two variants that preserve structural information but contain independent noise realizations. These are reconstructed separately, and the resulting pairs are used to train a denoising network directly in the image domain. We benchmark the proposed method against established analytical and self-supervised denoising approaches. In region-of-interest PBI CT experiments, Neighbor2Inverse achieves superior noise suppression while preserving fine structural details, as demonstrated by improved contrast-to-noise ratio, spatial resolution, and composite image quality metrics. Competitive performance is also observed on clinical CT data under simulated low-dose conditions. This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible. Code, data, and interactive figures are available at https://github.com/J-3TO/Neighbor2Inverse.

Implicit neural representations (INRs) have emerged as a powerful paradigm for medical imaging via physics-informed unsupervised learning. Classical INRs optimize an entire network from scratch for each subject, leading to inefficient training and suboptimal imaging quality. Recent initialization-based approaches attempt to inject population priors into pre-trained networks, yet they rely on high-quality images and often suffer from catastrophic forgetting during fine-tuning. We present DisINR, a novel INR framework that explicitly disentangles shared and subject-specific representations. DisINR introduces a shared encoder-decoder pair and subject-specific encoders, whose features are jointly decoded for image reconstruction. By integrating differentiable forward models, it pre-trains the shared modules directly from limited raw measurements, removing the need for pre-acquired high-quality images. During test-time adaptation, only the subject-specific encoder is optimized, while the shared pair remains frozen, effectively preserving learned priors. Extensive evaluations on three representative medical imaging tasks show that DisINR significantly outperforms state-of-the-art INRs in both reconstruction accuracy and efficiency.