Left-right asymmetry in predicting brain activity from LLMs' representations emerges with their formal linguistic competence

Brain-language model alignment is often interpreted as evidence that transformer models implement computations similar to those of the human brain. This assumes that neural predictivity reflects internal computational properties of large language models (LLMs), such as hierarchical contextual processing, predictive coding, or representational compression. An alternative possibility is that brain scores primarily reflect stable lexical-semantic correspondences shared by language models and the brain. Here we tested these interpretations using whole-brain encoding models across Mandarin, English, and French. Across all three languages, transformer representations significantly predicted activity in a distributed network spanning classical language regions, transmodal cortical systems, and subcortical structures. These spatial patterns showed substantial cross-linguistic overlap and remained remarkably stable across layers, providing little evidence that model depth systematically maps onto cortical processing hierarchies. Likewise, contextual transformer embeddings did not consistently outperform static lexical embeddings, despite providing some unique predictive variance. Finally, neither surprisal nor intrinsic dimensionality reproduced the layer-wise profile of brain scores, arguing against prediction and information compression as primary explanations for brain-LLM alignment. Together, these findings suggest that brain-LLM alignment is more robust across languages, transformer depth, and model architectures than previously appreciated, but less informative about shared computational mechanisms. Our results are more consistent with neural predictivity reflecting stable representational structure preserved across model transformations than with a one-to-one correspondence between their underlying computations.

The correspondence between large language models (LLMs) and the neural mechanisms underlying human higher-order cognition remains insufficiently characterized. Given that language and reasoning in the human brain appear dissociable, an open question is whether LLMs align with neural signals from reasoning-related regions and whether such signals can improve them. Here, focusing on deductive reasoning, we show that LLM internal representations are not only partially aligned with task-fMRI activity but can also be directly enhanced by these signals. Using a neural-predictivity metric, we find that LLMs explain a substantial fraction of the explainable variance in reasoning-related regions at the aggregate level, whereas predictivity within specific reasoning types is lower, indicating both alignment and divergence. Building on this, we propose a brain-guided framework: we steer model representations along directions induced by the joint structure of model and brain representations, applying intervention at inference and fine-tuning during training. We demonstrate that task-evoked brain signals can directly enhance LLM reasoning, yielding gains orthogonal to language-only supervision across 10 LLMs (1.5B-72B), with transfer across reasoning types and up to 13% absolute accuracy gain. Our results advance LLM-brain correspondences from correlation to guidance, establishing a brain-signal-driven pathway toward more robust and cognitively aligned AI.

Brain-LLM alignment is well established in English, yet the brain's language network is neuroanatomically universal across languages. Does alignment also generalize cross-linguistically, and what governs the variation? We test this using fMRI data from 112 participants across English, Chinese, and French (the Le Petit Prince corpus) and seven LLMs spanning English-dominant, Chinese-dominant, and multilingual architectures. Our central finding is that training-language dominance, not an inherent property of English, drives the alignment pattern: a Chinese-dominant model (Baichuan2-7B), architecture-matched to LLaMA-2-7B, reverses the gradient entirely, aligning best with Chinese brains and worst with English. Beyond training dominance, formal typological distance independently covaries with alignment degradation, syntax-associated brain regions (IFG) show $2.3\times$ steeper typological gradients than lexico-semantic regions (PTL), and tokenization fertility accounts for $\sim$60% of a cross-linguistic shift in optimal encoding layer. These results reveal that the apparent "English advantage" in brain-LLM alignment is an artifact of training data composition, while the remaining variation reflects genuine typological structure concentrated in syntactic processing.