Adversarial Data Modeling in Epidemiology

World models have emerged as a unifying paradigm for learning latent dynamics, simulating counterfactual futures, and supporting planning under uncertainty. In this paper, we argue that computational epidemiology is a natural and underdeveloped setting for world models. This is because epidemic decision-making requires reasoning about latent disease burden, imperfect and policy-dependent surveillance signals, and intervention effects are mediated by adaptive human behavior. We introduce a conceptual framework for epidemiological world models, formulating epidemics as controlled, partially observed dynamical systems in which (i) the true epidemic state is latent, (ii) observations are noisy and endogenous to policy, and (iii) interventions act as sequential actions whose effects propagate through behavioral and social feedback. We present three case studies that illustrate why explicit world modeling is necessary for policy-relevant reasoning: strategic misreporting in behavioral surveillance, systematic delays in time-lagged signals such as hospitalizations and deaths, and counterfactual intervention analysis where identical histories diverge under alternative action sequences.

This study presents a hybrid epidemiological and behavioural framework to simulate the spread of health misinformation on social media. We extend the classical Susceptible--Infected--Recovered (SIR) model to a six-compartment structure (SIRMMM), incorporating Misinformed Susceptible (MS), Misinformed Infected (MI), and Misinformed Recovered (MR) compartments to better reflect the dynamics of the misinformation lifecycle. To account for individual-level behavioural variation, we extend the SIRMMM model by integrating psychological signals from the Elaboration Likelihood Model (ELM), including sentiment polarity, engagement metrics, and cognitive effort, which dynamically modulate the misinformation transmission rate, yielding the ELM-SIRMMM framework. Model parameters were estimated using the FibVID dataset, which captures COVID-19 misinformation on Twitter. Generalisability was tested on two additional datasets: MC-Fake (emotional misinformation) and Monant (general health misinformation). Results show that the ELM-SIRMMM model enhances both predictive accuracy and dynamic realism. On FibVID, it decreases RMSE by 5.5%, delays the misinformation peak from day 150 to day 160, and increases its peak prevalence from 6% to 7%. On MC-Fake, it accurately reproduces a flash-rumour pattern, infecting 38% of users by day 45 and achieving 97% misinformation recovery, all while maintaining model accuracy. In contrast, minimal behavioural signal variability in the Monant dataset leads to marginal benefit, with only a 3% peak and 57% of users remaining susceptible. These findings suggest that structural elaboration alone is insufficient. Functional realism in modelling misinformation spread requires dynamic psychological inputs that vary meaningfully across time and contexts.

Epidemiological models often rely on survey data to represent how individuals make health-related decisions, such as whether to vaccinate or adopt protective behaviors. However, repeated large-scale surveys are costly, time-consuming, and limited in the range of scenarios they can capture. In this work, we investigate whether large language models (LLMs) can generate synthetic survey responses that reproduce patterns observed in real populations. Using longitudinal data from the FluPaths surveys, we first identify groups associated with broadly positive or negative attitudes toward vaccination through clustering analysis. We then evaluate several LLMs using a cluster-informed prompting approach to generate synthetic survey responses across multiple epidemic waves. Across models, the synthetic data generally reproduce the distributions of demographic characteristics, vaccination-related beliefs, risk perceptions, and health behaviors observed in the survey data. However, they are less successful at capturing how these factors vary together within respondents. Some models reproduce group-level vaccination trends more reliably than others, although performance varies across waves. We also trained a classifier to distinguish real from synthetic records and found that the generated responses remained identifiable as synthetic. Overall, our findings suggest that LLM-generated survey data may provide a useful tool for exploratory data augmentation and we hope that it could support agent-based epidemic modeling approaches. However, the generated data should not be treated as a substitute for human survey data without further methodological improvements and validation.