PreScience: A Dataset and Benchmark for Scientific Forecasting

Artificial intelligence (AI) is increasingly embedded in scientific discovery, yet whether it can anticipate scientific progress remains unclear. To study this question, we introduce a temporally grounded evaluation framework for forecasting scientific progress under controlled knowledge constraints. We present CUSP (Cutoff-conditioned Unseen Scientific Progress), a multi-disciplinary and event-level benchmark that evaluates scientific forecasting in AI systems through feasibility assessment, mechanistic reasoning, generative solution design, and temporal prediction. Across 4,760 scientific events, we observe systematic and domain-dependent limitations in current frontier models. While models can identify plausible research directions from competing candidates, they fail to reliably predict whether scientific advances will be realized and systematically misestimate when they will occur. Performance is highly heterogeneous across domains, with the timing of AI progress more predictable than advances in biology, chemistry, and physics. Performance is largely insensitive to whether events occur before or after the training cutoff, suggesting these limitations cannot be explained solely by knowledge exposure in training data. Under controlled information access, additional pre-cutoff knowledge improves performance but does not close the gap to full-information settings, which becomes more pronounced for high-citation advances. Models also exhibit systematic overconfidence and strong response biases, indicating unreliable uncertainty estimation. Taken together, current AI systems fall short as predictive tools for scientific progress. Access to prior knowledge does not translate into reliable forecasting, and performance benefits more from post-event information than from forward-looking prediction.

Scientific progress depends on sequences of enabling contributions, yet existing AI4Science benchmarks largely focus on citation prediction, literature retrieval, or idea generation rather than the dependencies that make progress possible. In this paper, we introduce discovery pathway forecasting: given a target scientific contribution and the prior literature available at a specified time, the task is to (1) identify the enabling contributions required to realize it and (2) ground each in prior work when such prior work exists. We present SciPaths, a benchmark of 262 expert-annotated gold pathways and 2,444 silver pathways constructed from machine learning and natural language processing papers, where each pathway records enabling contributions, roles, rationales, and prior-work groundings or unmapped decisions. Evaluating frontier and open-weight language models, we find that the best model reaches only 0.189 F1 under strict semantic matching, with core methodological dependencies hardest to recover. Prior-work grounding improves substantially when gold enabling contributions are provided, showing that decomposition quality is a major bottleneck for end-to-end pathway recovery. SciPaths therefore shifts evaluation toward a missing capability in scientific forecasting: reasoning backward from a target contribution to the enabling scientific building blocks and prior-work dependencies that make it feasible.

Large Language Models (LLMs) are increasingly used to brainstorm and evaluate research ideas, yet assessing such judgments is fundamentally difficult because the true impact of a new idea may take years to emerge. We address this challenge by using the impact forecasting of human-authored manuscripts as a verifiable proxy task. In a prospective forecasting study, we find that frontier LLMs fail to reliably distinguish high-impact papers from ordinary publications, suggesting that static text-based judging is insufficient for scientific evaluation. To address this limitation, we propose $\textbf{FAME}$ ($\underline{\text{F}}$orecasting $\underline{\text{A}}$cademic Impact via Continuous-Time $\underline{\text{M}}$anifold $\underline{\text{E}}$volution), a spatiotemporal framework for modeling the dynamic trajectories of scientific topics. FAME projects papers into a dynamic latent space informed by textual features and a verified knowledge-flow graph, learning geometric constraints that align impactful manuscripts with the forward momentum of their fields. Experiments on 3,200 arXiv papers across three fast-evolving subfields show that FAME consistently and substantially outperforms state-of-the-art LLM evaluators in prospective multidimensional impact forecasting. Furthermore, integrating FAME's dynamic geometric signals into LLMs significantly improves their forecasting performance. These results support manuscript impact forecasting as a useful, measurable proxy benchmark and position FAME as a strong, trajectory-aware foundation for automated scientific evaluation.