Percept-Aware Surgical Planning for Visual Cortical Prostheses with Vascular Avoidance
Organizations: Department of Computer Science, University of California Santa, Barbara · School of Computer Science, Carnegie Mellon University · Department of Psychological & Brain Sciences, University of California, Santa Barbara
Abstract
Cortical visual prostheses aim to restore sight by electrically stimulating neurons in early visual cortex (V1). With the emergence of high-density and flexible neural interfaces, electrode placement within three-dimensional cortex has become a critical surgical planning problem. Existing strategies emphasize visual field coverage and anatomical heuristics but do not directly optimize predicted perceptual outcomes under safety constraints. We present a percept-aware framework for surgical planning of cortical visual prostheses that formulates electrode placement as a constrained optimization problem in anatomical space. Electrode coordinates are treated as learnable parameters and optimized end-to-end using a differentiable forward model of prosthetic vision. The objective minimizes task-level perceptual error while incorporating vascular avoidance and gray matter feasibility constraints. Evaluated on simulated reading and natural image tasks using realistic folded cortical geometry (FreeSurfer fsaverage), percept-aware optimization consistently improves reconstruction fidelity relative to coverage-based placement strategies. Importantly, vascular safety constraints eliminate margin violations while preserving perceptual performance. The framework further enables co-optimization of multi-electrode thread configurations under fixed insertion budgets. These results demonstrate how differentiable percept models can inform anatomically grounded, safety-aware computer-assisted planning for cortical neural interfaces and provide a foundation for optimizing next-generation visual prostheses.
Figures & tables
| Baseline | Dataset | MSE | SSIM | Acc. |
|---|---|---|---|---|
| VF Tiling | MNIST | -67.7* [-73.6, -47.2] | 11.1* [7.8, 16.7] | 62.6* [28.9, 119.9] |
| VF Coverage | -33.4* [-42.0, -16.3] | 4.7* [3.1, 7.3] | 22.4* [7.8, 34.7] | |
| VF Tiling | CIFAR-10 | -58.4* [-87.4, -24.1] | 57.4* [35.3, 102.2] | 10.2* [5.5, 29.2] |
| VF Coverage | 16.0 [-25.2, 39.1] | -10.6 [-24.7, 0.2] | -2.2 [-9.1, 6.25] |
Brain-Computer Interfaces
Brain-computer interfaces translate neural activity into commands or feedback for communication, movement, rehabilitation, and sensory restoration.
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