DeepHistoViT: An Interpretable Vision Transformer Framework for Histopathological Cancer Classification

In this study, we proposed a deep Swin-Vision Transformer-based transfer learning architecture for robust multi-cancer histopathological image classification. The proposed framework integrates a hierarchical Swin Transformer with ResNet50-based convolution features extraction, enabling the model to capture both long-range contextual dependencies and fine-grained local morphological patterns within histopathological images. To validate the efficiency of the proposed architecture, an extensive experiment was executed on a comprehensive multi-cancer dataset including Breast Cancer, Oral Cancer, Lung and Colon Cancer, Kidney Cancer, and Acute Lymphocytic Leukemia (ALL), including both original and segmented images were analyzed to assess model robustness across heterogeneous clinical imaging conditions. Our approach is benchmarked alongside several state-of-the-art CNN and transfer models, including DenseNet121, DenseNet201, InceptionV3, ResNet50, EfficientNetB3, multiple ViT variants, and Swin Transformer models. However, all models were trained and validated using a unified pipeline, incorporating balanced data preprocessing, transfer learning, and fine-tuning strategies. The experimental results demonstrated that our proposed architecture consistently gained superior performance, reaching 100% test accuracy for lung-colon cancer, segmented leukemia datasets, and up to 99.23% accuracy for breast cancer classification. The model also achieved near-perfect precision, f1 score, and recall, indicating highly stable scores across divers cancer types. Overall, the proposed model establishes a highly accurate, interpretable, and also robust multi-cancer classification system, demonstrating strong benchmark for future research and provides a unified comparative assessment useful for designing reliable AI-assisted histopathological diagnosis and clinical decision-making.

Breast cancer is one of the most common types of cancer among women around the world. Rapid detection and early treatment can hinder its progress to more complex stages and can impede its spread to other parts of the body. Histopathological image classification is the most common task in cancer detection due to its robustness in analyzing cellular data. Breast histopathology classification requires handling both multi-scale tissue morphology and clinically relevant generalization beyond the source domain. This paper presents MagViT, an interpretable multi-magnification transformer framework with scale-gated fusion and patient-level model selection. The model uses four BreakHis magnifications (40X, 100X, 200X, 400X) and extracts per-scale representations with a ViT backbone, and combines them via a learnable gate that masks missing scales. Patient-level five-fold cross-validation with a fixed seed has been run and compared with three architectural branches. The most accurate branch is then selected as the final model due to the strongest patient-level accuracy while retaining the simplest fusion pathway. On BreakHis, our architecture achieves a mean image accuracy of 0.9191, a mean patient accuracy of 0.9643, and a mean macro-F1 of 0.9042. External transfer experiments provide preliminary evidence of cross-dataset generalization under controlled adaptation settings on BUSI (image accuracy 0.8306, macro-F1 0.7480, patient accuracy 0.8291) and IDC (image accuracy 0.8577, macro-F1 0.8191, patient accuracy 0.8372). Grad-CAM visualization indicates that the model focuses on diagnostically significant and meaningful regions across magnifications. Relative to prior ViT-centered BreakHis work, this study emphasizes patient-level selection and cross-dataset robustness under a reproducible protocol.

Lung cancer remains the leading cause of cancer-related mortality worldwide, while histopathological diagnosis is often affected by inter-observer variability and the substantial workload associated with manual slide examination. Although deep learning has shown considerable potential in computational pathology, comprehensive benchmarks that integrate tissue classification and region segmentation within a unified analytical framework remain limited. This study presents a two-stage deep learning framework for multi-class tissue classification and pixel-level histopathological region segmentation, accompanied by a systematic comparison of state-of-the-art architectures at each stage. For tissue classification, six models, a custom convolutional neural network, VGG16, DenseNet, MobileNetV3, a custom Vision Transformer, and YOLO11, are evaluated on a combined dataset of 39,000 images derived from LC25000 and LungHist700. The models distinguish between adenocarcinoma, squamous cell carcinoma, and normal lung tissue. YOLO11 achieves the best classification performance, with an accuracy of 98.38%, a five-fold cross-validation accuracy of 98.21 +/- 0.35%, and a macro F1-score of 0.98. For region segmentation, U-Net, ResNet-encoder U-Net, DeepLabV3+, and YOLO11-seg are evaluated using the GlaS gland segmentation benchmark. DeepLabV3+ obtains the highest Intersection over Union of 0.80 and a Dice score of 0.89, while YOLO11-seg achieves a comparable Intersection over Union of 0.79 using approximately 14x fewer parameters. The best-performing classification and segmentation models are subsequently integrated into an end-to-end framework, providing an accurate, computationally efficient, and reproducible baseline for automated histopathological image analysis.