Comprehensive Benchmarking of Deep Learning Architectures for Lung Cancer Histopathology

Histopathology remains the gold standard for cancer diagnosis because it provides detailed cellular-level assessment of tissue morphology. However, manual histopathological examination is time-consuming, labour-intensive, and subject to inter-observer variability, creating a demand for reliable computer-assisted diagnostic tools. Recent advances in deep learning, particularly transformer-based architectures, have shown strong potential for modelling complex spatial dependencies in medical images. In this work, we propose DeepHistoViT, a transformer-based framework for automated classification of histopathological images. The model employs a customized Vision Transformer architecture with an integrated attention mechanism designed to capture fine-grained cellular structures while improving interpretability through attention-based localization of diagnostically relevant regions. The framework is evaluated on three publicly available histopathology datasets covering lung cancer, colon cancer, and acute lymphoblastic leukaemia. Experimental results demonstrate state-of-the-art performance across all datasets, with classification accuracy, precision, recall, F1-score, and ROC-AUC reaching 100 percent on the lung and colon cancer datasets, and 99.85 percent, 99.84 percent, 99.86 percent, 99.85 percent, and 99.99 percent respectively on the acute lymphoblastic leukaemia dataset. All performance metrics are reported with 95 percent confidence intervals. These results highlight the effectiveness of transformer-based architectures for histopathological image analysis and demonstrate the potential of DeepHistoViT as an interpretable computer-assisted diagnostic tool to support pathologists in clinical decision-making.

In this study, we proposed a deep Swin-Vision Transformer-based transfer learning architecture for robust multi-cancer histopathological image classification. The proposed framework integrates a hierarchical Swin Transformer with ResNet50-based convolution features extraction, enabling the model to capture both long-range contextual dependencies and fine-grained local morphological patterns within histopathological images. To validate the efficiency of the proposed architecture, an extensive experiment was executed on a comprehensive multi-cancer dataset including Breast Cancer, Oral Cancer, Lung and Colon Cancer, Kidney Cancer, and Acute Lymphocytic Leukemia (ALL), including both original and segmented images were analyzed to assess model robustness across heterogeneous clinical imaging conditions. Our approach is benchmarked alongside several state-of-the-art CNN and transfer models, including DenseNet121, DenseNet201, InceptionV3, ResNet50, EfficientNetB3, multiple ViT variants, and Swin Transformer models. However, all models were trained and validated using a unified pipeline, incorporating balanced data preprocessing, transfer learning, and fine-tuning strategies. The experimental results demonstrated that our proposed architecture consistently gained superior performance, reaching 100% test accuracy for lung-colon cancer, segmented leukemia datasets, and up to 99.23% accuracy for breast cancer classification. The model also achieved near-perfect precision, f1 score, and recall, indicating highly stable scores across divers cancer types. Overall, the proposed model establishes a highly accurate, interpretable, and also robust multi-cancer classification system, demonstrating strong benchmark for future research and provides a unified comparative assessment useful for designing reliable AI-assisted histopathological diagnosis and clinical decision-making.

Liver cancer, especially hepatocellular carcinoma (HCC), imposes a substantial global disease burden. Accurate diagnosis and prognostic assessment directly influence treatment selection and patient survival, and pathological examination remains the gold standard for liver cancer diagnosis. Identifying diverse tissue components and pathological subtypes on histopathology slides is crucial for estimating postoperative recurrence risk and overall prognosis. However, most publicly available resources are still provided at the whole-slide image (WSI) level, and well-annotated datasets for fine-grained tissue component identification in liver cancer are scarce, which hinders reproducible model development and the deployment of quantitative analysis tools. To address this gap, we release HepatoBench, a patch-level image database for liver cancer with annotations for seven key tissue categories. Based on HepatoBench, we train and open-source a deep learning classification model as a tissue recognition tool. Furthermore, we train a WSI-level tumor/non-tumor segmentation model to automatically localize lesion regions across entire slides. By integrating the patch-level tissue classifier with the WSI-level segmentation model, we build HepatoQuant, an end-to-end, disease-specific regional quantification tool for liver cancer, enabling a unified workflow from WSIs to tissue composition parsing and quantitative statistics. We also open-source HepatoBench, the benchmarking protocol, and supporting tools, providing a solid foundation for automated regional quantification and fair method comparison in liver cancer pathology.