Eye image segmentation using visual and concept prompts with Segment Anything Model 3 (SAM3)

Is Segment Anything Model 3 (SAM3) capable in segmenting Any Pathology Images? Digital pathology segmentation spans tissue-level and nuclei-level scales, where traditional methods often suffer from high annotation costs and poor generalization. SAM3 introduces Promptable Concept Segmentation, offering a potential automated interface via text prompts. With this work, we propose a systematic evaluation protocol to explore the capability space of SAM3 in a structured manner. Specifically, we evaluate SAM3 under different supervision settings including zero-shot, few-shot, and supervised with varying prompting strategies. Our extensive evaluation on pathological datasets including NuInsSeg, PanNuke and GlaS, reveals that: (1) text-only prompts poorly activate nuclear concepts; (2) performance is highly sensitive to visual prompt types and budgets; (3) few-shot learning offers gains, but SAM3 lacks robustness against visual prompt noise; and (4) a significant gap persists between prompt-based usage and task-trained adapter-based reference. Our study delineates SAM3's boundaries in pathology image segmentation and provides practical guidance on the necessity of pathology domain adaptation.

The recent Segment Anything Model 3 (SAM3) extends powerful promptable segmentation from spatial cues to concepts, raising the prospect of a single foundation model for universal image segmentation. However, this promise often fails to translate into reliable performance on downstream segmentation tasks. In this work, we empirically identify concept recognition, rather than mask quality, as the primary bottleneck: SAM3 accurately delineates the objects it recognizes yet struggles to robustly determine which concepts are present. Driven by this, we present Text Anchor re-Grounding (\TAG{}), a simple yet effective framework that rectifies the concept recognition of SAM3 on the target domain without dense annotations. Specifically, \TAG{} introduces an Anchor Residual Pathway comprising image-conditioned, low-rank adapters to re-ground text anchors in the target distribution and modulate subsequent text-conditioned interactions. Guided solely by image-level category labels, \TAG{} jointly optimizes binary cross-entropy with Soft Boundary Ranking objectives to calibrate presence confidence and distinguish present concepts from confusable negatives. Building upon this, we devise Confidence-Weighted Distillation to couple rich semantic context of a multimodal large language model with fine-grained spatial priors of SAM3, thereby achieving effective calibration in the absence of manual annotations. Extensive experiments demonstrate that \TAG{} unlocks SAM3's segmentation potential with only 3.1M trainable parameters, achieving impressive performance across diverse scenarios, and notably, even surpassing leading mask-supervised methods on several metrics. Our code will be publicly available at GitHub \faGithub.

Real-time, on-device segmentation is critical for latency-sensitive and privacy-aware applications such as smart glasses and Internet-of-Things devices. We introduce PicoSAM3, a lightweight promptable visual segmentation model optimized for edge and in-sensor execution, including deployment on the Sony IMX500 vision sensor. PicoSAM3 has 1.3M parameters and combines a dense CNN architecture with region of interest prompt encoding, Efficient Channel Attention, and knowledge distillation from SAM2 and SAM3. On COCO and LVIS, PicoSAM3 achieves 65.45% and 64.01% mIoU, respectively, outperforming existing SAM-based and edge-oriented baselines at similar or lower complexity. The INT8 quantized model preserves accuracy with negligible degradation while enabling real-time in-sensor inference at 11.82ms latency on the IMX500, fully complying with its memory and operator constraints. Ablation studies show that distillation from large SAM models yields up to +14.5% mIoU improvement over supervised training and demonstrate that high-quality, spatially flexible promptable segmentation is feasible directly at the sensor level.