cs.AIMar 10, 2026

Algebraic Structure Discovery for Real World Combinatorial Optimisation Problems: A General Framework from Abstract Algebra to Quotient Space Learning

Authors: Min Sun, Federica Storti, Valentina Martino, Miguel Gonzalez-Andrades, Tony Kam-Thong

Organizations: F. Hoffmann-La Roche AG, Roche Pharma Research and Early Development

Abstract

Many combinatorial optimisation problems hide algebraic structures that, once exposed, shrink the search space and improve the chance of finding the global optimal solution. We present a general framework that (i) identifies algebraic structure, (ii) formalises operations, (iii) constructs quotient spaces that collapse redundant representations, and (iv) optimises directly over these reduced spaces. Across a broad family of rule-combination tasks (e.g., patient subgroup discovery and rule-based molecular screening), conjunctive rules form a monoid. Via a characteristic-vector encoding, we prove an isomorphism to the Boolean hypercube {0,1}n\{0,1\}^n with bitwise OR, so logical AND in rules becomes bitwise OR in the encoding. This yields a principled quotient-space formulation that groups functionally equivalent rules and guides structure-aware search. On real clinical data and synthetic benchmarks, quotient-space-aware genetic algorithms recover the global optimum in 48% to 77% of runs versus 35% to 37% for standard approaches, while maintaining diversity across equivalence classes. These results show that exposing and exploiting algebraic structure offers a simple, general route to more efficient combinatorial optimisation.

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