Organizations: Tsinghua University · DAMO Academy, Alibaba Group · Hupan Lab, 310023, Hangzhou, China · Zhejiang University · Key Laboratory of Pervasive Computing, Ministry of Education
Medical Vision-Language Models (VLMs) hold immense promise for complex clinical tasks, but their reasoning capabilities are often constrained by text-only paradigms that fail to ground inferences in visual evidence. This limitation not only curtails performance on tasks requiring fine-grained visual analysis but also introduces risks of visual hallucination in safety-critical applications. Thus, we introduce MedVR, a novel reinforcement learning framework that enables annotation-free visual reasoning for medical VLMs. Its core innovation lies in two synergistic mechanisms: Entropy-guided Visual Regrounding (EVR) uses model uncertainty to direct exploration, while Consensus-based Credit Assignment (CCA) distills pseudo-supervision from rollout agreement. Without any human annotations for intermediate steps, MedVR achieves state-of-the-art performance on diverse public medical VQA benchmarks, significantly outperforming existing models. By learning to reason directly with visual evidence, MedVR promotes the robustness and transparency essential for accelerating the clinical deployment of medical AI.
Figures & tables
Figure 1: MedVR enables verifiable visual reasoning via tool-use. In contrast to the visual hallucinations prevalent in text-only reasoning (left), MedVR (middle) interleaves textual deliberation with active image manipulation to achieve precise visual grounding. This synergy results in superior accuracy and robustness across multiple public medical VQA benchmarks (right).
Figure 2: Overview of MedVR. The framework employs EVR to explore visual actions based on the model’s intrinsic uncertainty and CCA to create a consensus-based reward from successful trajectories, enabling annotation-free training of medical visual reasoning.
Settings
General-Domain VQA (Multi-choice)
Modality-Specific VQA (Free-text)
Tasks
OMVQA
PMC-VQA ⋄
MedXQA ⋄
Avg.
VQA-RAD
SLAKE
PathVQA ⋄
Avg.
General-Purpose VLMs
Qwen2.5-VL-7B ( Bai et al., 2025a )
59.0
51.2
22.3
44.2
64.5
67.2
44.1
58.6
Qwen2.5-VL-32B ( Bai et al., 2025a )
69.9
54.1
24.5
49.5
71.8
71.2
41.9
61.6
InternVL2.5-8B ( Chen et al., 2024c )
83.9
51.3
21.0
52.1
59.4
69.0
42.1
56.8
InternVL3-8B ( Zhu et al., 2025 )
81.4
53.8
22.1
52.4
65.4
72.8
48.6
62.3
Table 1: Comprehensive performance comparison on medical VQA benchmarks, divided into General-Domain (multiple-choice) and Modality-Specific (free-text) tasks. Out-of-domain (OOD) test sets are marked with ⋄ . The best and second-best results are highlighted in bold and underlined .
Figure 3: Ablation study for key hyperparameters and reward design of MedVR.
Methods
Components
Performance
Zoom-in
EVR
CCA
OmniMedVQA
PMC-VQA
MedXpertQA
Textual RL
—
—
—
94.50
53.40
21.38
MedVR
✓
—
—
94.31
52.62
22.26
✓
✓
—
95.38
53.81
24.73
✓
—
✓
96.55
53.30
23.09
✓
✓
✓
96.77
54.31
26.38
Table 2: Ablation study for core components of MedVR.
Figure 6
Model
Method
OmniMedVQA
PMC-VQA
MedXpertQA
Avg.
Qwen2.5-VL-3B
Zero-shot
63.9
50.6
21.9
45.5
Textual RL
93.8
47.5
20.2
53.8
MedVR (Ours)
92.1
49.1
22.2
54.5
Qwen2.5-VL-7B
Zero-shot
64.3
51.2
22.3
46.0
Textual RL
94.5
53.4
21.4
56.4
MedVR (Ours)
96.7
54.3
26.4
59.1
Table 3: Performance of MedVR across model scales and variants.
Figure 7: Qualitative examples of MedVR’s visual reasoning process.
Appendix figures & tables10 assets
Supplementary material from the paper’s appendix.
Appendix
Model
Training Data
Training Methods
Key Benchmarks Involved in Training
Med-R1-2B
OmniMedVQA
RL
OmniMedVQA
MedVLM-R1-2B
HuatuoGPT-Vision Eval
RL
OmniMedVQA, PMC-VQA, VQA-RAD, SLAKE, PathVQA
MedGemma-4B
Proprietary curated data (33M)
Pretraining, SFT, RL
PMC-VQA, VQA-RAD, SLAKE and others
LLaVA-Med-7B
PMC-15M
SFT
PMC-VQA
HuatuoGPT-V-7B
PubMedVision (1.3M)
Pretraining,SFT
PMC-VQA
Lingshu-7B
Proprietary curated data (12M)
Pretraining, SFT, RL
PMC-VQA, MedXpertQA, VQA-RAD, SLAKE, PathVQA and others
Appendix
Table 4: Summary of training data, methodologies, and benchmark overlap for key baselines.
Table 10
Table 7: Performance on visual grounding and multimodal reasoning benchmarks.
Figure 8: Additional Visualization Results of MedVR’s Reasoning Process.
Figure 9: Average number of tool calls per trajectory during training.
Model
Total Tokens
Total Latency
Extra Visual Tokens
Extra Latency
MedVR
169.23
15.21s
84.76
0.23s (~1.5%)
Appendix
Table 8: Inference latency analysis for MedVR on the OmniMedVQA dataset.
Medical vision--language models (VLMs) have shown strong potential for medical visual question answering (VQA), yet their reasoning remains largely text-centric: images are encoded once as static context, and subsequent inference is dominated by language. This paradigm is fundamentally limited in clinical scenarios, where accurate answers often depend on subtle, localized visual evidence that cannot be reliably preserved in static embeddings. We propose MedLVR, a latent visual reasoning framework that introduces an explicit visual evidence state into autoregressive decoding. Instead of relying solely on text-based intermediate reasoning, MedLVR interleaves a short latent reasoning segment within the decoder by reusing hidden states as continuous latent steps, enabling iterative preservation and refinement of query-relevant visual evidence before answer generation. To support effective visual supervision, we adopt a two-stage training strategy: region of interest (ROI)-supervised fine-tuning aligns latent states with clinically relevant image evidence, and Visual-Latent Policy Optimization (VLPO) further optimizes latent reasoning and answer generation under outcome-level rewards. Experiments on OmniMedVQA and five external medical VQA benchmarks show that MedLVR consistently outperforms recent reasoning baselines and improves the average score over the Qwen2.5-VL-7B backbone from 48.3% to 53.4%. These results show that latent visual reasoning provides an effective mechanism for preserving diagnostically relevant visual evidence and improving the reliability of medical VQA.
Suyang Xi, Songtao Hu, Yuxiang Lai +4
Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, 30322, GA, USA · Department of Biostatistics and Bioinformatics, Emory University, Atlanta, 30322, GA, USA
Reinforcement learning (RL) is increasingly used to post-train medical Vision-Language Models (VLMs), yet it remains unclear whether RL improves medical visual reasoning or mainly sharpens behaviors already induced by supervised fine-tuning (SFT). We present a controlled study that disentangles these effects along three axes: vision, SFT, and RL. Using MedMNIST as a multi-modality testbed, we probe visual perception by benchmarking VLM vision towers against vision-only baselines, quantify reasoning support and sampling efficiency via Accuracy@1 versus Pass@K, and evaluate when RL closes the support gap and how gains transfer across modalities. We find that RL is most effective when the model already has non-trivial support (high Pass@K): it primarily sharpens the output distribution, improving Acc@1 and sampling efficiency, while SFT expands support and makes RL effective. Based on these findings, we propose a boundary-aware recipe and instantiate it by RL post-training an OctoMed-initialized model on a small, balanced subset of PMC multiple-choice VQA, achieving strong average performance across six medical VQA benchmarks.
Ahmadreza Jeddi, Kimia Shaban, Negin Baghbanzadeh +4
University of Toronto, Canada · Vector Institute, Canada · KITE Research Institute, University Health Network, Canada +1
Vision-language models have demonstrated impressive capabilities in general medical visual question answering, yet due to limited interpretability, it remains unclear whether their predictions reflect evidence-grounded clinical reasoning or reliance on spurious priors. We introduce Med-R2 Bench, a hierarchical benchmark aligned with the clinical workflow to evaluate adversarial robustness with visual grounding. We design stepwise QA tasks to assess whether reasoning chains are strictly grounded in visual evidence across the four clinical stages, and employ adversarial perturbations to test robustness against misleading cues. Med-R2 comprises 42,432 images, 31 task categories, and 110,406 QA pairs. Evaluation across 14 VLMs reveals a sequential performance degradation along the four-stage clinical workflow. Adversarial experiments show that models rely heavily on correct prompts to guess answers. Even when provided with explicit visual cues, the models struggle to accurately align textual descriptions. Finally, we demonstrate stepwise fine-tuning using our hierarchical data significantly improves reasoning robustness, highlighting its potential to drive future improvements in evidence-based medical AI.
Wen Ma, Fucheng Niu, Zhiting Fan +3
Zhejiang University, Zhejiang, China · Guangdong Institute of Intelligence Science and Technology