EviSearch: Trustworthy Extraction and Synthesis of Clinical Trial Evidence with Agents that Improve with Use

Systematic reviews underpin clinical guidelines, yet their data-extraction step is a major expert-labor bottleneck bound by a protocolized workflow: two reviewers extract each study independently, an adjudicator resolves disagreements, and the team keeps an auditable record of how every value was produced. Large language models can assist with extraction, but that assistance must fit established review protocols and preserve reproducibility. We present EviStreams, a live, open-source, no-code web platform that puts review teams in control of AI-assisted extraction at three key stages: program design (a structured decomposition approved before any code runs), field specification (typed field definitions calibrated from a pilot), and extracted predictions (reviewer-blinded dual review with adjudication). Working through a form builder, a domain expert defines typed fields rather than prompts, runs extraction over uploaded PDFs, inspects every value alongside the supporting passage it came from, and resolves a reviewer-blinded dual review into an auditable consensus export. An evaluation across four clinical corpora and three frontier model families, released with the system, shows that extraction quality is shaped far more by the field specification than by the choice of model. EviStreams is live at https://evistreams.com/demo and released under Apache-2.0.

Scientific peer review generation has attracted increasing attention for reducing reviewing burdens and providing timely feedback. However, existing Large Language Model (LLM)-based methods often produce generic comments with insufficient evidence support and weak source traceability, while complex multi-agent systems incur high inference costs. To address these challenges, we propose EGTR-Review, an Evidence-Grounded and Traceable Review Generation framework via Multi-Agent Teacher Distillation. EGTR-Review first constructs a multi-agent teacher that performs structure-aware paper decomposition, key-element extraction, external scholarly evidence retrieval, evidence-state labeling, verification reasoning, and review synthesis. It then distills both intermediate reasoning trajectories and final review comments into a lightweight student model through task-prefix-driven multi-task learning. An evidence-weighted objective further reduces the influence of weak, missing, or non-verifiable supervision. Experiments on public peer-review datasets show that EGTR-Review (Student) outperforms strong prompt-based, fine-tuned, and structured/agentic baselines across automatic metrics, LLM-as-Judge evaluation, and human evaluation, while maintaining strong factual grounding and source traceability with substantially lower token consumption and inference time. Our code, prompts, configurations, and sample data are available on GitHub.

Self-evolving agents should not train on examples they cannot justify. Data-free self-evolving search agents offer a scalable route to systems that generate their own questions, answer them, and improve from their own feedback without human annotations. Yet, without verifiable evidence, this loop can reward fluent but unsupported examples, turning the self-generated curriculum into an opaque and potentially unreliable training signal. We argue that evidence verifiability is a prerequisite for trustworthy self-evolution in search agents: each generated instance should include not only an answer but also a source-grounded span whose contribution to that answer can be measured. We introduce EVE-Agent, an Evidence-Verifiable Self-Evolving Agent that operationalizes this principle through a modification to the proposer--solver framework. The proposer generates a question, an answer, and a verbatim evidence span. An evidence verifier then rewards the span according to the marginal accuracy gain when the evidence is provided. This produces a training signal that favors evidence that genuinely helps answer the question, without requiring oracle answers, human labels, or external annotations. EVE-Agent leaves the backbone model, retriever, search tool, and optimization framework unchanged. Experiments show that EVE-Agent substantially improves evidence-grounded correctness over prior self-evolving search agents. The resulting curriculum is not merely self-generated but auditable by construction: each training example carries an inspectable source span that explains why it should be trusted.