LLM-guided phase diagram construction through high-throughput experimentation

Modern generative machine learning (ML) models can propose novel inorganic crystalline materials with targeted properties; however, synthesis planning of these materials remains difficult due to the complexity of the associated physical processes and limited availability of computational tools. We introduce a novel hybrid framework to evaluate Large Language Models (LLMs) in inorganic synthesis planning by combining thermodynamic databases with simplified kinetics models to approximate realistic synthesis conditions. As a case study, we focus on the niobium-oxygen system, which features multiple industrially relevant oxide phases with well-characterized data. In computational simulations, we compare LLM-generated synthesis routes with classical path-planning algorithms, showing that the implicit priors in LLMs can yield more viable strategies. In our evaluation setting, classical search methods serve primarily as a foil rather than a direct competitor. This illustrates the relative complexity of the problem and highlights where the LLM's implicit priors add value.

Materials phase diagrams are a core knowledge representation in materials science, encoding temperature,composition, phase stability, and phase transformation pathways, with their full understanding requiring thermodynamic mechanism analysis and scientific reasoning. Although VLMs have shown promise in scientific image understanding, their systematic evaluation on such logically complex images demanding deep mechanistic interpretation remains limited, and phase diagrams provide a challenging testbed for this purpose. We introduce MatPhaseBench, a high-quality, high-reliability benchmark for complex scientific image understanding, focused on materials phase diagrams. MatPhaseBench is constructed from 3681 papers in classical materials science journals, from which 200 high-quality diagram-text pairs were selected, covering 189 material systems and 70 elements. The benchmark has three key features: (1)targeting complex scientific image understanding-it moves beyond simple objective tests to open-ended tasks requiring deep comprehension; (2)comprehensive image-text alignment-semantic information associated with images is fully preserved during literature mining and matching; (3) high-quality human-supervised text acquisition-all descriptions undergo strict manual validation. Experimental results show that current VLMs remain substantially behind expert-level understanding: they are largely limited to surface visual perception, lack deep reasoning grounded in thermodynamic mechanisms, have limited domain awareness and expert analytical experience, and perform poorly in distinguishing fine-grained differences in composite or multi-diagram settings. Overall, MatPhaseBench constitutes a challenging research-grade benchmark, providing a foundational platform for complex scientific image understanding, phase diagram analysis, and trustworthy multi-modal AI in science.

Phase-field modeling provides a powerful approach for predicting microstructure evolution but becomes computationally prohibitive for multicomponent and multiphase systems over large spatial and temporal scales. This work presents an AE-GCN-LSTM surrogate framework for long-horizon forecasting of microstructure evolution in the multicomponent AlCrFeNi high-entropy alloy system containing coexisting BCC and FCC phases. A multi-head autoencoder compresses the four elemental concentration fields and phase-field order parameter into latent representations, which are formulated as graphs for learning their spatial and temporal evolution. The framework accurately forecasts microstructure evolution over horizons extending to 3,000,000 simulation timesteps. Its robustness is systematically evaluated under previously unseen conditions without retraining, fine-tuning, or parameter adaptation. These evaluations include variations in FCC precipitate size and initial position, microstructures containing one, two, and five FCC precipitates, and complex phase interactions involving precipitate merging and splitting. Although trained only on 100 x 100 computational domains containing a single nominal alloy composition, the framework is successfully transferred to larger 256 x 256 and 512 x 512 systems and to previously unseen AlCrFeNi compositions. Across the evaluated configurations, the model preserves the dominant phase morphology and compositional evolution while providing computational speedups ranging from approximately 7200 to 62300 relative to conventional phase-field simulations. These results demonstrate that latent graph-based AE-GCN-LSTM forecasting provides a scalable and computationally efficient surrogate for long-horizon simulation of multicomponent, multiphase microstructures and offers a promising foundation for high-throughput alloy design.